ZFYVE19 - zinc finger FYVE-type containing 19 Gene

Homo sapiens

Also known as ANCHR; PFIC9; MPFYVE

Gene ID: 84936 | Gene type: protein coding

About ZFYVE19

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,807,089-40,815,084 (from NCBI)

This gene has 16 transcripts (splice variants), 193 orthologues, 13 paralogues and is associated with 2 phenotypes. Ubiquitous expression in duodenum (RPKM 6.2), small intestine (RPKM 6.1) and 25 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity. Involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE19 Products(4)

mRNA	Protein	Name
NM_001077268.2	NP_001070736.1	abscission/NoCut checkpoint regulator isoform 1
NM_001258420.2	NP_001245349.1	abscission/NoCut checkpoint regulator isoform 2
NM_001258421.2	NP_001245350.1	abscission/NoCut checkpoint regulator isoform 4
NM_032850.5	NP_116239.3	abscission/NoCut checkpoint regulator isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	24814515	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in abscission	IMP IMP: Inferred from mutant phenotype	24814515	GOA
involved in mitotic cytokinesis checkpoint signaling	IMP IMP: Inferred from mutant phenotype	24814515	GOA
involved in negative regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	24814515	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	24814515	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	24814515	GOA
located in midbody	IDA IDA: Inferred from direct assay	24814515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE19 Protein Structure

FYVE

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

abscission/NoCut checkpoint regulator

MLL partner containing FYVE domain

ZFYVE19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFYVE19	Q96K21	CAPN7	Homo sapiens	Q7Z479	Y2H Prey Pooling	25416956
Intra	ZFYVE19	Q96K21	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	ZFYVE19	Q96K21	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	ZFYVE19	Q96K21	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	ZFYVE19	Q96K21	VPS4B	Homo sapiens	O75351	Y2H Array	31515488
Intra	ZFYVE19	Q96K21	VPS4B	Homo sapiens	O75351	Validated Y2H	25416956
Intra	ZFYVE19	Q96K21	VPS4B	Homo sapiens	O75351	Y2H Array	25416956
Intra	ZFYVE19	Q96K21	VPS4B	Homo sapiens	O75351	Y2H Prey Pooling	25416956
Intra	ZFYVE19	Q96K21	MITD1	Homo sapiens	Q8WV92	Y2H Prey Pooling	25416956
Intra	ZFYVE19	Q96K21	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	ZFYVE19	Q96K21	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	ZFYVE19	Q96K21	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	ZFYVE19	Q96K21	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	ZFYVE19	Q96K21	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cholestasis, Progressive Familial Intrahepatic, 9

PFIC9

Ileocolitis

Iieocolitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16057	ZFYVE19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZFYVE19	VGNC	VGNC:67239
Macaca mulatta	ZFYVE19	VGNC	VGNC:99348
Bos taurus	ZFYVE19	VGNC	VGNC:37175
Rattus norvegicus	ZFYVE19	RGD	RGD:1561576
Mus musculus	ZFYVE19	MGD	MGI:1919258
Canis familiaris	ZFYVE19	VGNC	VGNC:48624

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