MITD1 - microtubule interacting and trafficking domain containing 1 Gene

Homo sapiens (human)

Gene ID: 129531 | Gene type: protein coding

About MITD1

Summary

Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

MITD1 Products(1)

mRNA	Protein	Name
NM_001320419.2	NP_001307348.1	MIT domain-containing protein 1 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23015756	GOA
enables phosphatidylinositol binding	IMP IMP: Inferred from mutant phenotype	23045692	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16730941	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	23015756	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	23015756	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	23045692	GOA
NOT involved in multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	23015756	GOA
involved in negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	23015756	GOA
NOT involved in viral budding via host ESCRT complex	IMP IMP: Inferred from mutant phenotype	23045692	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	23045692	GOA
colocalizes with midbody	IDA IDA: Inferred from direct assay	23045692	GOA
located in midbody	IMP IMP: Inferred from mutant phenotype	23015756	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MIT domain-containing protein 1

MIT, microtubule interacting and transport, domain containing 1

MITD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21-3	Y2H Prey Pooling	25416956
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21-3	Validated Y2H	25416956
Intra	MITD1	Q8WV92	CHMP1A	Homo sapiens	Q9HD42	Validated Y2H	32296183
Intra	MITD1	Q8WV92	GPHN	Homo sapiens	Q9NQX3-2	Validated Y2H	32296183
Intra	MITD1	Q8WV92	GPHN	Homo sapiens	Q9NQX3-2	Y2H Array	32296183
Intra	MITD1	Q8WV92	GPHN	Homo sapiens	Q9NQX3-2	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	RTN3	Homo sapiens	O95197-3	Y2H Array	32296183
Intra	MITD1	Q8WV92	RTN3	Homo sapiens	O95197-3	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	CHMP1B	Homo sapiens	Q7LBR1	Y2H Array	32296183
Intra	MITD1	Q8WV92	CHMP1B	Homo sapiens	Q7LBR1	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	TTC33	Homo sapiens	Q6PID6	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	TTC33	Homo sapiens	Q6PID6	Y2H Array	32296183
Intra	MITD1	Q8WV92	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21	Validated Y2H	32296183
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21	Y2H Array	25416956
Intra	MITD1	Q8WV92	CHMP2A	Homo sapiens	O43633	Y2H	16730941
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21	Y2H Array	32296183
Intra	MITD1	Q8WV92	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	MITD1	Q8WV92	CHMP2A	Homo sapiens	O43633	Anti Tag CoIP	16730941
Intra	MITD1	Q8WV92	ZFYVE19	Homo sapiens	Q96K21	Validated Y2H	25416956
Intra	MITD1	Q8WV92	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MITD1	Q8WV92	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MITD1	Q8WV92	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	MITD1	Q8WV92	CHMP5	Homo sapiens	Q9NZZ3	Y2H Prey Pooling	25416956
Intra	MITD1	Q8WV92	CHMP5	Homo sapiens	Q9NZZ3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

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