FRMD5 - FERM domain containing 5 Gene

Homo sapiens

Also known as NEDEMA

Gene ID: 84978 | Gene type: protein coding

About FRMD5

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,870,764-44,199,473 (from NCBI)

This gene has 12 transcripts (splice variants), 306 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.9), heart (RPKM 4.6) and 4 other tissues.

Summary

Enables Integrin binding activity and protein kinase binding activity. Involved in negative regulation of cell motility; positive regulation of cell adhesion; and regulation of cell migration. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]

FRMD5 Products(7)

mRNA	Protein	Name
NM_001286490.2	NP_001273419.1	FERM domain-containing protein 5 isoform 3
NM_001286491.2	NP_001273420.1	FERM domain-containing protein 5 isoform 4
NM_001322949.2	NP_001309878.1	FERM domain-containing protein 5 isoform 6
NM_001322950.2	NP_001309879.1	FERM domain-containing protein 5 isoform 7
NM_001322951.2	NP_001309880.1	FERM domain-containing protein 5 isoform 8
NM_001411124.1	NP_001398053.1	FERM domain-containing protein 5 isoform 9
NM_032892.5	NP_116281.2	FERM domain-containing protein 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IDA IDA: Inferred from direct assay	25448675	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22846708	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	25448675	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell motility	IMP IMP: Inferred from mutant phenotype	25448675	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	25448675	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22846708	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	22846708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRMD5 Protein Structure

FERM_N

FERM_M

FERM_C

0
100
200
300
400
500
570 a.a.

Protein Preferred Names

Protein Names

FERM domain-containing protein 5

FRMD5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FRMD5	Q7Z6J6	ITGB5	Homo sapiens	P18084	Anti Tag CoIP	25448675
Intra	FRMD5	Q7Z6J6	CTNND1	Homo sapiens	O60716	Anti Bait CoIP	22846708
Intra	FRMD5	Q7Z6J6	CTNND1	Homo sapiens	O60716	IF	22846708
Intra	FRMD5	Q7Z6J6	CTNND1	Homo sapiens	O60716	Anti Tag CoIP	22846708
Intra	FRMD5	Q7Z6J6	ROCK1	Homo sapiens	Q13464	Anti Bait CoIP	25448675
Intra	FRMD5	Q7Z6J6	ROCK1	Homo sapiens	Q13464	Anti Tag CoIP	25448675

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05103	FRMD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FRMD5	VGNC	VGNC:29116
Canis familiaris	FRMD5	VGNC	VGNC:40982
Macaca mulatta	FRMD5	VGNC	VGNC:72797
Felis catus	FRMD5	VGNC	VGNC:62362
Rattus norvegicus	FRMD5	RGD	RGD:1561554
Mus musculus	FRMD5	MGD	MGI:2442557

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