ROCK1 - Rho associated coiled-coil containing protein kinase 1 Gene

Homo sapiens

Also known as ROCK-I; P160ROCK

Gene ID: 6093 | Gene type: protein coding

About ROCK1

Cytogenetic location: 18q11.1 Genomic coordinates (GRCh38): 18:20,946,906-21,111,813 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 22.1), fat (RPKM 16.6) and 25 other tissues.

Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

ROCK1 Products(1)

mRNA	Protein	Name
NM_005406.3	NP_005397.1	rho-associated protein kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Rho-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18573880	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10652353	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10652353	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	27160703	GOA
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in cortical actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	12082081	GOA
involved in leukocyte migration	IDA IDA: Inferred from direct assay	12082081	GOA
involved in leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	12082081	GOA
involved in membrane to membrane docking	IDA IDA: Inferred from direct assay	12082081	GOA
involved in negative regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in negative regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19181962	GOA
involved in negative regulation of bicellular tight junction assembly	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	18573880	GOA
involved in neuron projection arborization	IGI IGI: Inferred from genetic interaction	27160703	GOA
involved in neuron projection development	IGI IGI: Inferred from genetic interaction	27160703	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	18573880	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	28679962	GOA
involved in positive regulation of amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	27853422	GOA
involved in positive regulation of autophagy	IGI IGI: Inferred from genetic interaction	27853422	GOA
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	28679962	GOA
involved in positive regulation of connective tissue replacement	IMP IMP: Inferred from mutant phenotype	28679962	GOA
involved in positive regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	27221467	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27853422	GOA
involved in positive regulation of phosphatase activity	IMP IMP: Inferred from mutant phenotype	27221467	GOA
involved in protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	23093407	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	25911094	GOA
involved in regulation of angiotensin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	28679962	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	23093407	GOA
involved in regulation of establishment of endothelial barrier	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	19997641	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	23093407	GOA
involved in regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	27160703	GOA
involved in regulation of synaptic vesicle endocytosis	IGI IGI: Inferred from genetic interaction	27160703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROCK1 Protein Structure

Pkinase

Pkinase_C

HR1

Rho_Binding

0
300
600
900
1200
1354 a.a.

Protein Preferred Names

Protein Names

rho-associated protein kinase 1

p160 ROCK-1

renal carcinoma antigen NY-REN-35

ROCK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ROCK1	Q13464	TSG101	Homo sapiens	Q99816	Y2H	17853893
Intra	ROCK1	Q13464	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	17853893
Intra	ROCK1	Q13464	RHOA	Homo sapiens	P61586	X-Ray Diffraction	14660612
Intra	ROCK1	Q13464	RHOA	Homo sapiens	P61586	Pull Down	21281639
Intra	ROCK1	Q13464	POLR3C	Homo sapiens	Q9BUI4	Y2H Array	25416956
Intra	ROCK1	Q13464	FRMD5	Homo sapiens	Q7Z6J6	Anti Bait CoIP	25448675
Intra	ROCK1	Q13464	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	ROCK1	Q13464	FAM124A	Homo sapiens	Q86V42	Validated Y2H	25416956
Intra	ROCK1	Q13464	FAM124A	Homo sapiens	Q86V42	Y2H Array	25416956
Intra	ROCK1	Q13464	CFAP206	Homo sapiens	Q8IYR0	Y2H Prey Pooling	25416956
Intra	ROCK1	Q13464	MAGEB4	Homo sapiens	O15481	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Omphalocele

Omphalocoele	Congenital Omphalocele
Exomphalos	Exumbilication

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.91%	Unkown
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.96%	Yes
HY-15307	Belumosudil	Inhibitor	99.83%	Yes
HY-15685	Ripasudil	Inhibitor	99.95%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-10341A	Fasudil	Inhibitor	/	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	/	Unkown
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	98.54%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-15687A	SAR407899	Inhibitor	99.60%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Phase 2
HY-16071	AT13148	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15392	Chroman 1	Inhibitor	99.42%	Unkown
HY-15556	GSK269962A	Inhibitor	99.83%	Unkown
HY-11000	GSK429286A	Inhibitor	98.17%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	Unkown
HY-15755	RKI-1447	Inhibitor	98.29%	Unkown
HY-13300	SR-3677	Inhibitor	99.83%	Unkown
HY-18990	GSK180736A	Inhibitor	98.81%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-12437	BDP5290	Inhibitor	98.80%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-14362	GSK-25	Inhibitor	99.68%	Unkown
HY-16758	Verosudil	Inhibitor	99.18%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	98.04%	Unkown
HY-126275	HSD1590	Inhibitor	99.54%	Unkown
HY-122011	PF-4950834	Inhibitor	/	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	99.11%	Unkown
HY-132302	Hu7691	Inhibitor	/	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-107209	RKI-1313	Inhibitor	98.2%	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-162596	NRL-1049	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	/	Unkown
HY-125221	DJ4	Inhibitor	98.48%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ROCK1	MGD	MGI:107927
Macaca mulatta	ROCK1	VGNC	VGNC:81559
Bos taurus	ROCK1	VGNC	VGNC:56371
Canis familiaris	ROCK1	VGNC	VGNC:45688
Felis catus	ROCK1	VGNC	VGNC:97608
Rattus norvegicus	ROCK1	RGD	RGD:620424
Others	ROCK1	NCBI

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