2. Gene
  3. RANBP3 - RAN binding protein 3 Gene

RANBP3 - RAN binding protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8498 | Gene type: protein coding

About RANBP3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,916,139-5,978,140 (from NCBI)

This gene has 30 transcripts (splice variants), 215 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 18.0), lung (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RANBP3 Products(4)

mRNA Protein Name
NM_001300865.2 NP_001287794.1 ran-binding protein 3 isoform 4
NM_003624.3 NP_003615.2 ran-binding protein 3 isoform RANBP3-a
NM_007320.3 NP_015559.2 ran-binding protein 3 isoform RANBP3-b
NM_007322.3 NP_015561.1 ran-binding protein 3 isoform RANBP3-d
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
19289081 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9637251 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
9637251 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10567565 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9637251 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANBP3 Protein Structure

Ran_BP1

Ran_BP1: RanBP1 domain (390 - 497)

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  • 567 a.a.
Protein Preferred Names Protein Names

ran-binding protein 3

epididymis secretory sperm binding protein

RANBP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RANBP3 Q9H6Z4 SMAD2 Homo sapiens Q15796
Pull Down
21960005
Intra RANBP3 Q9H6Z4 PPM1A Homo sapiens P35813
Pull Down
21960005
Intra RANBP3 Q9H6Z4 PPM1A Homo sapiens P35813
Anti Tag CoIP
21960005
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11646 RANBP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11647 RANBP3L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RANBP3 RGD RGD:1589604
Canis familiaris RANBP3 VGNC VGNC:45339
Mus musculus RANBP3 MGD MGI:1919060
Felis catus RANBP3 VGNC VGNC:69232
Bos taurus RANBP3 VGNC VGNC:33710
Macaca mulatta RANBP3 VGNC VGNC:76655