ENC1 - ectodermal-neural cortex 1 Gene

Homo sapiens

Also known as NRPB; CCL28; ENC-1; PIG10; KLHL35; KLHL37; TP53I10

Gene ID: 8507 | Gene type: protein coding

About ENC1

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:74,627,409-74,640,728 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 2 paralogues. Biased expression in brain (RPKM 180.1), gall bladder (RPKM 11.8) and 4 other tissues.

Summary

This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

ENC1 Products(4)

mRNA	Protein	Name
NM_001256574.2	NP_001243503.1	ectoderm-neural cortex protein 1 isoform 1
NM_001256575.2	NP_001243504.1	ectoderm-neural cortex protein 1 isoform 1
NM_001256576.2	NP_001243505.1	ectoderm-neural cortex protein 1 isoform 2
NM_003633.4	NP_003624.1	ectoderm-neural cortex protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19424503	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	19424503	GOA
involved in proteasomal ubiquitin-independent protein catabolic process	IDA IDA: Inferred from direct assay	19424503	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15983046	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15983046	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19424503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENC1 Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
589 a.a.

Protein Preferred Names

Protein Names

ectoderm-neural cortex protein 1

ectodermal-neural cortex 1 (with BTB domain)

Related Diseases

Diseases

Alias

Necrotizing Gastritis

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04369	ENC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENC1	RGD	RGD:1303152
Felis catus	ENC1	VGNC	VGNC:61857
Bos taurus	ENC1	VGNC	VGNC:28489
Mus musculus	ENC1	MGD	MGI:109610
Canis familiaris	ENC1	VGNC	VGNC:40359
Macaca mulatta	ENC1	VGNC	VGNC:72217

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