2. Gene
  3. MICALL1 - MICAL like 1 Gene

MICALL1 - MICAL like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MIRAB13; MICAL-L1

Gene ID: 85377 | Gene type: protein coding

About MICALL1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,906,297-37,942,822 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues.

Summary

Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MICALL1 Products(4)

mRNA Protein Name
NM_001410818.1 NP_001397747.1 MICAL-like protein 1 isoform 1
NM_001410819.1 NP_001397748.1 MICAL-like protein 1 isoform 2
NM_001410820.1 NP_001397749.1 MICAL-like protein 1 isoform 4
NM_033386.4 NP_203744.1 MICAL-like protein 1 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23596323 GOA
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
23596323 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19864458 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
19864458 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
19864458 GOA
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
20801876 GOA
involved in plasma membrane tubulation IDA
IDA: Inferred from direct assay
23596323 GOA
involved in protein localization to endosome IMP
IMP: Inferred from mutant phenotype
23596323 GOA
involved in protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
19864458 GOA
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
21795389 GOA
involved in slow endocytic recycling IMP
IMP: Inferred from mutant phenotype
19864458 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic side of endosome membrane IDA
IDA: Inferred from direct assay
19864458 GOA
NOT located in early endosome IDA
IDA: Inferred from direct assay
21795389 GOA
located in late endosome IDA
IDA: Inferred from direct assay
21795389 GOA
NOT located in recycling endosome membrane IDA
IDA: Inferred from direct assay
21795389 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
19864458 GOA
NOT located in trans-Golgi network IDA
IDA: Inferred from direct assay
21795389 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICALL1 Protein Structure

CH

CH: Calponin homology (CH) domain (7 - 107)

LIM

LIM: LIM domain (164 - 217)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (678 - 817)

  • 0
  • 200
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  • 800
  • 863 a.a.
Protein Preferred Names Protein Names

MICAL-like protein 1

molecule interacting with Rab13

MICALL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MICALL1 Q8N3F8 EHD4 Homo sapiens Q9H223
Pull Down
19864458
Intra
MICALL1 Q8N3F8 EHD4 Homo sapiens Q9H223
Anti Tag CoIP
33961781
Intra
MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Y2H
19864458
Intra
MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Anti Tag CoIP
33961781
Intra
MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Y2H
27189942
Intra
MICALL1 Q8N3F8 EHD3 Homo sapiens Q9NZN3
Pull Down
19864458
Intra
MICALL1 Q8N3F8 EHD1 Homo sapiens Q9H4M9
Pull Down
19864458
Intra
MICALL1 Q8N3F8 EHD1 Homo sapiens Q9H4M9
Anti Tag CoIP
33961781
Cross
MICALL1 Q8N3F8 DPYSL2 Bos taurus O02675
Pull Down
20801876
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bardet-Biedl Syndrome 5

BBS5

Bardet-Biedl Syndrome, Type 5
Microvillus Inclusion Disease

Congenital Microvillous Atrophy

Intractable Diarrhea Of Infancy

Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities

Davidson Disease

Microvillous Inclusion Disease

Congenital Microvillus Atrophy

Mvid

Diarrhea 2 With Microvillus Atrophy

Mvd

Congenital Familial Protracted Diarrhea

Davidson'S Disease

Familial Enteropathy, Microvillus

Microvillus Atrophy, Congenital

Congenital Enteropathy

Familial Protracted Enteropathy

Microvillous Atrophy

Microvillus Atrophy With Diarrhea 2

Idi
Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1
Retinitis Pigmentosa 39

RP39

Retinitis Pigmentosa, Type 39
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08428 MICALL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MICALL1 VGNC VGNC:54528
Bos taurus MICALL1 VGNC VGNC:52803
Macaca mulatta MICALL1 VGNC VGNC:107801
Felis catus MICALL1 VGNC VGNC:97508
Mus musculus MICALL1 MGD MGI:105870
Rattus norvegicus MICALL1 RGD RGD:1305415