BARX2 - BARX homeobox 2 Gene

Homo sapiens

Gene ID: 8538 | Gene type: protein coding

About BARX2

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,375,233-129,452,279 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 3 paralogues. Biased expression in esophagus (RPKM 46.6), salivary gland (RPKM 29.6) and 9 other tissues.

Summary

This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin Cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in Cancer progression. [provided by RefSeq, Jul 2008]

BARX2 Products(1)

mRNA	Protein	Name
NM_003658.5	NP_003649.2	homeobox protein BarH-like 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10854790	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	14744868	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14744868	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14744868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BARX2 Protein Structure

Homeobox

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

homeobox protein BarH-like 2

BarH-like homeobox 2

Related Diseases

Diseases

Alias

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01369	BARX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BARX2	RGD	RGD:1584840
Bos taurus	BARX2	VGNC	VGNC:26424
Felis catus	BARX2	VGNC	VGNC:69123
Canis familiaris	BARX2	VGNC	VGNC:38383
Mus musculus	BARX2	MGD	MGI:109617
Macaca mulatta	BARX2	VGNC	VGNC:107424

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