API5 - apoptosis inhibitor 5 Gene

Homo sapiens

Also known as AAC11; AAC-11

Gene ID: 8539 | Gene type: protein coding

About API5

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:43,311,996-43,344,529 (from NCBI)

This gene has 11 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 18.0), lymph node (RPKM 15.7) and 25 other tissues.

Summary

This gene encodes an Apoptosis inhibitory protein whose expression prevents Apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced Apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

API5 Products(4)

mRNA	Protein	Name
NM_001142930.2	NP_001136402.1	apoptosis inhibitor 5 isoform a
NM_001142931.2	NP_001136403.1	apoptosis inhibitor 5 isoform c
NM_001243747.2	NP_001230676.1	apoptosis inhibitor 5 isoform d
NM_006595.4	NP_006586.1	apoptosis inhibitor 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	11075807	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19387494	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11075807	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11075807	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

API5 Protein Structure

API5

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

apoptosis inhibitor 5

FIF

API5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	API5	Q9BZZ5	DDX39B	Homo sapiens	Q13838	Crosslink	30021884
Intra	API5	Q9BZZ5	ACIN1	Homo sapiens	Q9UKV3-3	Anti Tag CoIP	19387494

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Asbestos-Related Lung Carcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00819	API5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	API5	VGNC	VGNC:99544
Bos taurus	API5	VGNC	VGNC:26015
Canis familiaris	API5	VGNC	VGNC:37985
Felis catus	API5	VGNC	VGNC:67744
Rattus norvegicus	API5	RGD	RGD:1309772
Mus musculus	API5	MGD	MGI:1888993

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