PPFIA3 - PTPRF interacting protein alpha 3 Gene

Homo sapiens

Also known as LPNA3

Gene ID: 8541 | Gene type: protein coding

About PPFIA3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,119,544-49,151,026 (from NCBI)

This gene has 13 transcripts (splice variants), 283 orthologues and 5 paralogues. Biased expression in brain (RPKM 10.8), skin (RPKM 6.5) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane Protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize Phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]

PPFIA3 Products(1)

mRNA	Protein	Name
NM_003660.4	NP_003651.1	liprin-alpha-3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12923177	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	23124857	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPFIA3 Protein Structure

SAM_1

SAM_2

0
200
400
600
800
1000
1194 a.a.

Protein Preferred Names

Protein Names

liprin-alpha-3

liprin

PPFIA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPFIA3	O75145	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	PPFIA3	O75145	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	PPFIA3	O75145	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	PPFIA3	O75145	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	PPFIA3	O75145	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	PPFIA3	O75145	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	PPFIA3	O75145	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	PPFIA3	O75145	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	PPFIA3	O75145	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	PPFIA3	O75145	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	PPFIA3	O75145	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	PPFIA3	O75145	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	PPFIA3	O75145	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Najm Type

Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia	Micpch
X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10941	PPFIA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPFIA3	VGNC	VGNC:76236
Canis familiaris	PPFIA3	VGNC	VGNC:44845
Bos taurus	PPFIA3	VGNC	VGNC:33191
Rattus norvegicus	PPFIA3	RGD	RGD:620054
Mus musculus	PPFIA3	MGD	MGI:1924037
Felis catus	PPFIA3	VGNC	VGNC:68983

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