ZFHX2 - zinc finger homeobox 2 Gene

Homo sapiens

Also known as ZFH5; ZFH-5; MARSIS; ZNF409

Gene ID: 85446 | Gene type: protein coding

About ZFHX2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,520,857-23,555,952 (from NCBI)

This gene has 4 transcripts (splice variants), 169 orthologues, 20 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 3.0), brain (RPKM 0.7) and 5 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of sensory perception of pain. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZFHX2 Products(1)

mRNA	Protein	Name
NM_033400.3	NP_207646.2	zinc finger homeobox protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of sensory perception of pain	IMP IMP: Inferred from mutant phenotype	29253101	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	29253101	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFHX2 Protein Structure

zf-C2H2_2

Homeobox

0
400
800
1200
1600
2000
2400
2572 a.a.

Protein Preferred Names

Protein Names

zinc finger homeobox protein 2

ZFH-2

ZFHX2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFHX2	Q9C0A1	MAPT	Homo sapiens	P10636	Y2H Pooling	32814053
Intra	ZFHX2	Q9C0A1	MAPT	Homo sapiens	P10636	Validated Y2H	32814053
Intra	ZFHX2	Q9C0A1	MAPT	Homo sapiens	P10636	Y2H Array	32814053
Intra	ZFHX2	Q9C0A1	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ZFHX2	Q9C0A1	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ZFHX2	Q9C0A1	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Marsili Syndrome

Congenital Insensitivity To Pain	Congenital Analgesia, Autosomal Dominant
MARSIS	Insensitivity To Pain, Congenital, Autosomal Dominant
Congenital Analgesia	Congenital Indifference To Pain
Hereditary Sensory And Autonomic Neuropathy Type V	Hereditary Sensory And Autonomic Neuropathy
Channelopathy-Associated Cip	Channelopathy-Associated Congenital Insensitivity To Pain
Congenital Insensitivity To Pain And Thermal Analgesia	Hsan V
Hsan5	Hereditary Sensory And Autonomic Neuropathy Type 5
Insensitivity To Pain, Congenital	Neuropathy, Hereditary Sensory And Autonomic, Type V
Hsan	Hereditary Sensory Autonomic Neuropathy
Asymbolia For Pain	Channelopathy-Associated Insensitivity To Pain
Cip	Congenital Pain Indifference
Indifference To Pain, Congenital, Autosomal Recessive	Pain Insensitivity, Congenital

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome	Del(8)(Q21.11)
Deletion 8q21.11	Monosomy 8q21.11

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16035	ZFHX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZFHX2	MGD	MGI:2686934
Macaca mulatta	ZFHX2	VGNC	VGNC:99346
Bos taurus	ZFHX2	VGNC	VGNC:37156
Canis familiaris	ZFHX2	VGNC	VGNC:48606
Felis catus	ZFHX2	VGNC	VGNC:80786
Rattus norvegicus	ZFHX2	RGD	RGD:735143

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