TNKS1BP1 - tankyrase 1 binding protein 1 Gene

Homo sapiens

Also known as TAB182

Gene ID: 85456 | Gene type: protein coding

About TNKS1BP1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,299,642-57,324,952 (from NCBI)

This gene has 7 transcripts (splice variants), 112 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues.

Summary

Enables ankyrin repeat binding activity and Enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including actin cytoskeleton; adherens junction; and heterochromatin. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

TNKS1BP1 Products(1)

mRNA	Protein	Name
NM_033396.3	NP_203754.2	182 kDa tankyrase-1-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ankyrin repeat binding	IMP IMP: Inferred from mutant phenotype	11854288	GOA
enables ankyrin repeat binding	IPI IPI: Inferred from physical interaction	11854288	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	11854288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11854288	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25749521	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	25749521	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	25749521	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	25749521	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	25749521	GOA
involved in positive regulation of protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	25749521	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in adherens junction	IDA IDA: Inferred from direct assay	11854288	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11854288	GOA
located in heterochromatin	IDA IDA: Inferred from direct assay	11854288	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11854288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS1BP1 Protein Structure

Tankyrase_bdg_C

0
300
600
900
1200
1500
1729 a.a.

Protein Preferred Names

Protein Names

182 kDa tankyrase-1-binding protein

tankyrase 1 binding protein 1, 182kDa

TNKS1BP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNKS1BP1	Q9C0C2	FHL2	Homo sapiens	Q14192	Anti Bait CoIP	33787085
Intra	TNKS1BP1	Q9C0C2	TOB1	Homo sapiens	P50616	TAP	18377426

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Alcohol-Induced Mental Disorder

Psychoses, Alcoholic

Substance-Induced Psychosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14842	TNKS1BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNKS1BP1	MGD	MGI:2446193
Rattus norvegicus	TNKS1BP1	RGD	RGD:1312021
Canis familiaris	TNKS1BP1	VGNC	VGNC:47682
Macaca mulatta	TNKS1BP1	VGNC	VGNC:79181
Felis catus	TNKS1BP1	VGNC	VGNC:66422
Bos taurus	TNKS1BP1	VGNC	VGNC:36185

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