TOB1 - transducer of ERBB2, 1 Gene

Homo sapiens

Also known as TOB; TROB; APRO5; APRO6; PIG49; TROB1

Gene ID: 10140 | Gene type: protein coding

About TOB1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,862,223-50,867,978 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues.

Summary

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

TOB1 Products(3)

mRNA	Protein	Name
NM_001243877.2	NP_001230806.1	protein Tob1 isoform 1
NM_001243885.2	NP_001230814.1	protein Tob1 isoform 2
NM_005749.4	NP_005740.1	protein Tob1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18377426	GOA
enables receptor tyrosine kinase binding	IDA IDA: Inferred from direct assay	8632892	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8632892	GOA
involved in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	18377426	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	23236473	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	21336257	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	21336257	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	21336257	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOB1 Protein Structure

BTG

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

protein Tob1

proliferation-inducing gene 49

TOB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TOB1	P50616	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	18377426
Intra	TOB1	P50616	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	28514442
Intra	TOB1	P50616	CNOT10	Homo sapiens	Q9H9A5	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	18377426
Intra	TOB1	P50616	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	33961781
Intra	TOB1	P50616	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	28514442
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	GMS	19276069
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	Pull Down	19276069
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	Y2H Array	31515488
Intra	TOB1	P50616	RAVER1	Homo sapiens	Q8IY67	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CPEB4	Homo sapiens	Q17RY0	Anti Tag CoIP	21336257
Intra	TOB1	P50616	CPEB4	Homo sapiens	Q17RY0	Pull Down	21336257
Intra	TOB1	P50616	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TOB1	P50616	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TOB1	P50616	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TOB1	P50616	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TOB1	P50616	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TOB1	P50616	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TOB1	P50616	CNOT9	Homo sapiens	Q92600	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT9	Homo sapiens	Q92600	Anti Tag CoIP	28514442
Intra	TOB1	P50616	CNOT9	Homo sapiens	Q92600	TAP	18377426
Intra	TOB1	P50616	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	TOB1	P50616	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	TOB1	P50616	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	TOB1	P50616	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	28514442
Intra	TOB1	P50616	PABPC1	Homo sapiens	P11940	ITC	20595394
Intra	TOB1	P50616	PABPC1	Homo sapiens	P11940	NMR	20595394
Intra	TOB1	P50616	CPEB3	Homo sapiens	Q8NE35	Pull Down	21336257
Intra	TOB1	P50616	CPEB3	Homo sapiens	Q8NE35	Anti Tag CoIP	21336257

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14872	TOB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TOB1	VGNC	VGNC:78613
Mus musculus	TOB1	MGD	MGI:1349721
Felis catus	TOB1	VGNC	VGNC:82316
Bos taurus	TOB1	VGNC	VGNC:36212
Canis familiaris	TOB1	VGNC	VGNC:49663
Rattus norvegicus	TOB1	RGD	RGD:621126

Name
Email *

	Sorry, but the email address you supplied was invalid.