DIXDC1 - DIX domain containing 1 Gene

Homo sapiens

Also known as CCD1

Gene ID: 85458 | Gene type: protein coding

About DIXDC1

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,927,315-112,022,653 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 11.3), endometrium (RPKM 10.0) and 23 other tissues.

Summary

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

DIXDC1 Products(3)

mRNA	Protein	Name
NM_001037954.4	NP_001033043.1	dixin isoform a
NM_001278542.2	NP_001265471.1	dixin isoform c
NM_033425.5	NP_219493.1	dixin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	19375513	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17043677	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	21189423	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19375513	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIXDC1 Protein Structure

DIX

0
200
400
600
682 a.a.

Protein Preferred Names

Protein Names

dixin

coiled-coil protein DIX1

DIXDC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	DIXDC1	Q155Q3	Dvl2	Mus musculus	Q60838	NMR	21189423
Intra	DIXDC1	Q155Q3	DVL2	Homo sapiens	O14641	Anti Bait CoIP	20823832
Intra	DIXDC1	Q155Q3	NDEL1	Homo sapiens	Q9GZM8	Y2H	17043677

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03785	DIXDC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DIXDC1	VGNC	VGNC:39969
Macaca mulatta	DIXDC1	VGNC	VGNC:71694
Bos taurus	DIXDC1	VGNC	VGNC:28077
Rattus norvegicus	DIXDC1	RGD	RGD:1309902
Mus musculus	DIXDC1	MGD	MGI:2679721
Felis catus	DIXDC1	VGNC	VGNC:102875

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