2. Gene
  3. NDEL1 - nudE neurodevelopment protein 1 like 1 Gene

NDEL1 - nudE neurodevelopment protein 1 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EOPA; NDE2; NUDEL; MITAP1; NDE1L1

Gene ID: 81565 | Gene type: protein coding

About NDEL1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,413,131-8,474,328 (from NCBI)

This gene has 19 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), adrenal (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

NDEL1 Products(3)

mRNA Protein Name
NM_001025579.3 NP_001020750.1 nuclear distribution protein nudE-like 1 isoform A
NM_001330129.2 NP_001317058.1 nuclear distribution protein nudE-like 1 isoform C
NM_030808.5 NP_110435.1 nuclear distribution protein nudE-like 1 isoform B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10931877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10931877 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
17600710 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
21283621 GOA
involved in regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
21283621 GOA
Cellular Component GO Annotation Evidence Reference Source
located in kinetochore IDA
IDA: Inferred from direct assay
17600710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDEL1 Protein Structure

NUDE_C

NUDE_C: NUDE protein, C-terminal conserved region (135 - 336)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

nuclear distribution protein nudE-like 1

endooligopeptidase A

NDEL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NDEL1 Q9GZM8 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra NDEL1 Q9GZM8 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 ZNF572 Homo sapiens Q7Z3I7
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF572 Homo sapiens Q7Z3I7
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 MBIP Homo sapiens Q9NS73-5
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
Intra NDEL1 Q9GZM8 BORCS6 Homo sapiens Q96GS4
Y2H Array
32296183
Intra NDEL1 Q9GZM8 BORCS6 Homo sapiens Q96GS4
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 ZNF844 Homo sapiens Q08AG5
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF844 Homo sapiens Q08AG5
Y2H Array
25416956
Intra NDEL1 Q9GZM8 ZNF260 Homo sapiens Q3ZCT1
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF662 Homo sapiens Q6ZS27-3
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 ZNF662 Homo sapiens Q6ZS27-3
Y2H Array
32296183
Intra NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 CEP135 Homo sapiens Q66GS9
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 CEP135 Homo sapiens Q66GS9
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
Intra NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 DIXDC1 Homo sapiens Q155Q3
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 DIXDC1 Homo sapiens Q155Q3
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 CCSER1 Homo sapiens Q9C0I3
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 CCSER1 Homo sapiens Q9C0I3
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 IMMT Homo sapiens Q16891-1
Y2H
20880836
Intra NDEL1 Q9GZM8 IMMT Homo sapiens Q16891-1
Pull Down
20880836
Intra NDEL1 Q9GZM8 PXN Homo sapiens P49023-2
Anti Tag CoIP
19492042
Intra NDEL1 Q9GZM8 PXN Homo sapiens P49023-2
Pull Down
19492042
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971-2
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971-2
Y2H Array
32296183
Intra NDEL1 Q9GZM8 CLVS2 Homo sapiens Q5SYC1
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 CLVS2 Homo sapiens Q5SYC1
Y2H Array
32296183
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-1
Y2H
17043677
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-1
Far-WB
20880836
Intra NDEL1 Q9GZM8 BMI1 Homo sapiens P35226
Y2H Array
25416956
Intra NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra NDEL1 Q9GZM8 ZNF264 Homo sapiens Q14C61
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF264 Homo sapiens Q14C61
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 BRK1 Homo sapiens Q8WUW1
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49
Y2H Array
25416956
Intra NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49
Y2H Array
31515488
Intra NDEL1 Q9GZM8 ZNF445 Homo sapiens P59923
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 ZNF445 Homo sapiens P59923
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 XPA Homo sapiens P23025
Y2H Array
25416956
Intra NDEL1 Q9GZM8 XPA Homo sapiens P23025
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra NDEL1 Q9GZM8 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra NDEL1 Q9GZM8 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra NDEL1 Q9GZM8 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra NDEL1 Q9GZM8 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra NDEL1 Q9GZM8 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra NDEL1 Q9GZM8 GSN Homo sapiens P06396
Y2H Array
32814053
Intra NDEL1 Q9GZM8 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086
Y2H Array
32296183
Intra NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5
Y2H
12812986
Intra NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 CWF19L2 Homo sapiens Q2TBE0
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra NDEL1 Q9GZM8 PKP2 Homo sapiens Q99959
Y2H Array
25416956
Intra NDEL1 Q9GZM8 PKP2 Homo sapiens Q99959
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 CCSER2 Homo sapiens Q9H7U1
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 CCSER2 Homo sapiens Q9H7U1
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 NDC80 Homo sapiens O14777
Y2H Array
29892012
Intra NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra NDEL1 Q9GZM8 PAFAH1B1 Homo sapiens P43034
Y2H
10931877
Intra NDEL1 Q9GZM8 PAFAH1B1 Homo sapiens P43034
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 DTNB Homo sapiens O60941
Y2H Array
25416956
Intra NDEL1 Q9GZM8 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 NUP54 Homo sapiens Q7Z3B4
Y2H Fragment Pooling
31413325
Intra NDEL1 Q9GZM8 NUP54 Homo sapiens Q7Z3B4
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
Intra NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
Intra NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
Intra NDEL1 Q9GZM8 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra NDEL1 Q9GZM8 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 USP2 Homo sapiens O75604
Y2H Array
25416956
Intra NDEL1 Q9GZM8 AIMP2 Homo sapiens Q13155
Y2H Array
25416956
Intra NDEL1 Q9GZM8 AIMP2 Homo sapiens Q13155
Y2H Prey Pooling
25416956
Intra NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228
Y2H Array
25416956
Intra NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 ZNF57 Homo sapiens Q68EA5
Y2H Array
32296183
Intra NDEL1 Q9GZM8 ZNF57 Homo sapiens Q68EA5
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 ZNF599 Homo sapiens Q96NL3
Validated Y2H
25416956
Intra NDEL1 Q9GZM8 ZNF599 Homo sapiens Q96NL3
Y2H Array
25416956
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Crosslink
22843697
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Light Scattering
22843697
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
GMS
22843697
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
32296183
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Y2H Array
25416956
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Y2H
10931877
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Comigration in SDS
22843697
Intra NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
X-Ray Diffraction
17997972
Intra NDEL1 Q9GZM8 NDE1 Homo sapiens Q9NXR1
Anti Tag CoIP
33961781
Intra NDEL1 Q9GZM8 CENPF Homo sapiens P49454
Fluorescence
17600710
Intra NDEL1 Q9GZM8 CENPF Homo sapiens P49454
Y2H
17600710
Intra NDEL1 Q9GZM8 CENPF Homo sapiens P49454
Y2H Fragment Pooling
31413325
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly
Lissencephaly 4

LIS4

Lissencephaly 4 With Microcephaly

Microlissencephaly

Lissencephaly, Type 4
Lissencephaly 1

LIS1

Classic Lissencephaly

Ils

Subcortical Laminar Heterotopia

Lissencephaly Due To Lis1 Mutation

Lissencephaly Sequence, Isolated

Lissencephaly, Classic

Pafah1b1-Related Lissencephaly

Classical Lissencephaly

Lissencephaly Type 1

Lissencephaly-1

Subcortical Band Heterotopia

Double Cortex

Lissencephaly Classic

Lissencephaly Sequence Isolated

Isolated Lissencephaly Sequence

Type 1 Lissencephaly

Lissencephaly Syndrome Type 1

SBH

Sclh

Lissencephaly, Type 1

Type I Lissencephaly
Microlissencephaly
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)
Neuronopathy, Distal Hereditary Motor, Type Viib

HMN7B

Hmn Viib

Dhmn7b

Neuropathy, Distal Hereditary Motor, Type Viib

Distal Hereditary Motor Neuronopathy Type 7b

Distal Hereditary Motor Neuropathy Type Viib

Neuronopathy, Distal Hereditary Motor, Type 7b

Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

Lower Motor Neuron Disease, Dynactin Type

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

Harper-Young Myopathy

Neuronopathy, Distal Hereditary Motor, 7b

Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

Lower Motor Neuron Disease Dynactin Type

Plmnd

Progressive Lower Motor Neuron Disease

Neuropathy, Motor, Distal, Hereditary, Type Viib
Band Heterotopia

Subcortical Band Heterotopia

Double Cortex Syndrome

Subcortical Laminar Heterotopia

Double Cortex

Band Heterotopia Of Brain

BH

Heco

Heterotopic Cortex

Familial Band Heterotopia

Dc

Dc Syndrome

Heterotopia, Subcortical Band

Sbh

Sclh

Bhy
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09107 NDEL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NDEL1 VGNC VGNC:31933
Rattus norvegicus NDEL1 RGD RGD:621235
Canis familiaris NDEL1 VGNC VGNC:43672
Mus musculus NDEL1 MGD MGI:1932915
Macaca mulatta NDEL1 VGNC VGNC:74982
Felis catus NDEL1 VGNC VGNC:63749