Dvl2 - dishevelled segment polarity protein 2 Gene

Mus musculus

Gene ID: 13543 | Gene type: protein coding

About Dvl2

Summary

Enables several functions, including Enzyme binding activity; Frizzled binding activity; and identical protein binding activity. Involved in several processes, including outflow tract morphogenesis; positive regulation of GTPase activity; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of protein tyrosine kinase activity; and segment specification. Located in several cellular components, including apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and retina. Used to study dextro-looped transposition of the great arteries. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dvl2 Products(1)

mRNA	Protein	Name
NM_007888.4	NP_031914.3	segment polarity protein dishevelled homolog DVL-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	20802536	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	17529994	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12805222	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15579909	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17244647	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	23109420	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	23109420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	25190059	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	16116426	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	8887313	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17606995	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	10409711	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18093802	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	16116426	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IGI IGI: Inferred from genetic interaction	16571627	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IMP IMP: Inferred from mutant phenotype	16571627	MGI
acts upstream of or within convergent extension involved in organogenesis	IGI IGI: Inferred from genetic interaction	16116426	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	12421720	MGI
involved in heart looping	IGI IGI: Inferred from genetic interaction	22841628	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	19008950	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	12421720	MGI
involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	22841628	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	12464179	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	23109420	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	10829020	MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	19920076	MGI
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	17606995	MGI
acts upstream of or within segment specification	IMP IMP: Inferred from mutant phenotype	12421720	MGI
involved in segmentation	IGI IGI: Inferred from genetic interaction	8887313	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	19300477	MGI
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	17005174	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17244647	MGI
located in cytosol	IDA IDA: Inferred from direct assay	21189423	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	23533177	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	19465938	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16116426	MGI
located in plasma membrane	IGI IGI: Inferred from genetic interaction	17606995	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

segment polarity protein dishevelled homolog DVL-2

DSH homolog 2	dishevelled 2, dsh homolog
dishevelled-2

Dvl2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dvl2	Q60838	DIXDC1	Homo sapiens	Q155Q3	GMS	21189423
Intra	Dvl2	Q60838	DIXDC1	Homo sapiens	Q155Q3	Solution Sedimentation	21189423
Intra	Dvl2	Q60838	DIXDC1	Homo sapiens	Q155Q3	Pull Down	21189423
Intra	Dvl2	Q60838	Dvl3	Mus musculus	Q61062	Confocal	21092292
Cross	Dvl2	Q60838	DAAM1	Homo sapiens	Q9Y4D1-1	Anti Tag CoIP	18162551
Cross	Dvl2	Q60838	DAAM1	Homo sapiens	Q9Y4D1-1	Pull Down	18162551
Intra	Dvl2	Q60838	Vangl1	Mus musculus	Q80Z96	Anti Bait CoIP	15456783
Intra	Dvl2	Q60838	Vangl2	Mus musculus	Q91ZD4	Y2H	15456783
Intra	Dvl2	Q60838	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	21718540
Intra	Dvl2	Q60838	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	19701191
Cross	Dvl2	Q60838	WWOX	Homo sapiens	Q9NZC7	Anti Tag CoIP	25678599
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Anti Bait CoIP	22609948
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Peptide Array	22609948
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Pull Down	22609948
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Anti Tag CoIP	22609948
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	GMS	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	Solution Sedimentation	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	Pull Down	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	GMS	21189423
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	TEM	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	Solution Sedimentation	21189423
Cross	Dvl2	Q60838	CSNK1E	Homo sapiens	P49674	Pull Down	22609948
Cross	Dvl2	Q60838	CSNK1D	Homo sapiens	P48730	Protein Kinase Assay	22609948
Cross	Dvl2	Q60838	Ap2m1	Rattus norvegicus	P84092	Pull Down	20947020
Cross	Dvl2	Q60838	Ap2m1	Rattus norvegicus	P84092	GMS	20947020

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100853	IWP-O1	Inhibitor	99.81%	Unkown
HY-RS04077	DVL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dvl2	NCBI	NCBI:1856

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