TSLP - thymic stromal lymphopoietin Gene

Homo sapiens

Gene ID: 85480 | Gene type: protein coding

About TSLP

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,070,062-111,078,026 (from NCBI)

This gene has 3 transcripts (splice variants) and 65 orthologues. Broad expression in gall bladder (RPKM 3.6), liver (RPKM 3.0) and 15 other tissues.

Summary

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying Antibacterial and Antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]

TSLP Products(2)

mRNA	Protein	Name
NM_033035.5	NP_149024.1	thymic stromal lymphopoietin isoform 1 precursor
NM_138551.5	NP_612561.2	thymic stromal lymphopoietin isoform 2

TSLP Protein Structure

TSLP

0
100
159 a.a.

Protein Preferred Names

Protein Names

thymic stromal lymphopoietin

Recombinant TSLP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7057	TSLP Protein, Human	Q969D9-1 (Y29-Q159)	≥95%
HY-P70818	TSLP Protein, Human (HEK293, His)	Q969D9-1 (Y29-Q159)	≥95%
HY-P78224	TSLP Protein, Human (Biotinylated, HEK293, His-Avi)	Q969D9-1 (Y29-Q159)	≥95%
HY-P78225	TSLP Protein, Human (Biotinylated, R127A, R130A, HEK293, His-Avi)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥95%
HY-P78532	TSLP Protein, Human (HEK293, His-Avi)	Q969D9-1 (Y29-Q159)	≥95%
HY-P78533	TSLP Protein, Human (R127A, R130A, HEK293, His-Avi)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥95%
HY-P78658	TSLP Protein, Human (R127A, R130A, HEK293, His)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥95%
HY-P78659	TSLP Protein, Human (R127A, R130A, HEK293, mFc)	Q969D9-1 (Y29-Q159, R127A, R130A)	≥95%
HY-P700601	TSLP Protein, Human (HEK293, His-Myc)	Q969D9-1 (Y29-Q159)	≥95%

Related Diseases

Diseases

Alias

Cryoglobulinemia

Cryoimmunoglobulinaemia

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis	Dense Deposit Disease
Membranoproliferative Glomerulonephritis Type 2	Primary Membranoproliferative Glomerulonephritis
Mesangiocapillary Glomerulonephritis, Type Ii	Glomerulonephritis, Membranoproliferative
Chronic Glomerulonephritis, Lobular	Lobular Glomerulonephritis
Ddd	Glomerulonephritis Membranoproliferative Type 2
Mpgn 2	Membranoproliferative Glomerulonephritis Type Ii
Mesangiocapillary Glomerulonephritis Type 2	Mpgn
Primary Mpgn	Glomerulonephritis Membranoproliferative
Membranoproliferative Glomerulonephritis, Type Ii

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Cryoglobulinemia, Familial Mixed

Cryoglobulinemic Vasculitis	Essential Mixed Cryoglobulinemia
Mixed Cryoglobulinemia	Essential Cryoglobulinemia
Primary Cryoglobulinemia	Meltzer Syndrome
Familial Mixed Cryoglobulinemia

Esophagitis

Acute Esophagitis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

T2-Low Asthma

Type 2 Low Endotype

Respiratory Allergy

Airway Allergy

Chronic Asthma

Eczema Herpeticum

Herpes Simplex Dermatitis	Herpes Simplex Eyelid Dermatitis
Kaposi Varicelliform Eruption	Herpes Simplex Dermatitis Of Eyelid
Herpes Simplex Virus Dermatitis	Herpes Simplex Virus Eyelid Dermatitis

Nasal Cavity Disease

Disorder Of Nasal Cavity

Rhinitis

Runny Nose

T2-High Asthma

Type 2 High Endotype

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency	SCIDX1
XSCID	Scidx
X-Linked Scid	X-Scid
Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Scid, X-Linked
Immunodeficiency 4	Imd4
Gamma Chain Deficiency	Scid-X1
X-Linked Combined Immunodeficiency Diseases	Thymic Epithelial Hypoplasia
Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency	Severe Combined Immunodeficiency T- B+, X-Linked
Il2rg Scid, T- B+ Nk-	T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
T-B+ Scid Due To Gamma Chain Deficiency	T-B+ Severe Combined Immunodeficiency, X-Linked
Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative	Agammaglobulinemia Swiss Type
Scid X-Linked	Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative
Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative	Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Legume Allergy

Fabaceae Allergy

Acute Asthma

Occupational Asthma

Environmental Induced Asthma

Irritant Asthma

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Intrinsic Asthma

Non-Atopic Asthma

Neurodermatitis

Peanut Allergy

Allergy To Peanuts	Peanut Allergic Reaction
Allergies Peanut	Peanut Hypersensitivity

Fruit Allergy

Allergy To Fruit

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Chronic Conjunctivitis

Dermatitis, Atopic, 3

ATOD3	Dermatitis, Atopic, Susceptibility To, 3
Atopic Dermatitis 3	Dermatitis, Atopic, With Asthma
Dermatitis, Atopic 3	Atopic Dermatitis With Asthma

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Intermittent Asthma

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Allergic Conjunctivitis

Conjunctivitis Allergic	Conjunctivitis, Allergic
Allergen-Induced Conjunctivitis	Seasonal Allergic Conjunctivitis
Perennial Allergic Conjunctivitis	Spring Conjunctivitis
Acute Allergic Conjunctivitis

Goat Milk Allergy

Capra Hircus Milk Allergy

Glomerulonephritis

Bright'S Disease

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Egg Allergy

Allergy To Eggs	Allergies Egg
Egg Hypersensitivity

Eosinophilic Gastritis

Eosinophilic Enteropathy

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Irritant Dermatitis

Irritant Contact Dermatitis	Primary Irritant Dermatitis
Dermatitis, Irritant	Contact Dermatitis, Irritant
Irritant Contact Eczema	Icd - [Irritant Contact Dermatitis]
Irritant Contact Dermatitis, Unspecified Cause	Non-Allergic Contact Dermatitis
Irritant Contact Eczema Due To Wet Work	Irritant Contact Dermatitis Due To Detergents
Irritant Contact Eczema Due To Solvents	Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants
Irritant Contact Eczema Due To Cosmetics Or Emollients	Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials
Irritant Contact Eczema Due To Plants Or Other Vegetable Matter	Irritant Contact Eczema Due To Foods
Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids	Irritant Contact Eczema Due To Saliva
Irritant Contact Eczema Due To Incontinence	Incontinence-Associated Dermatitis

Persistent Severe Asthma

Near-Fatal Asthma

Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax	Spontaneous Pneumothorax
Familial Spontaneous Pneumothorax	PSP
Pneumothorax

Trichinosis

Trichinellosis	Human Trichinellosis
Trichiniasis	Trichinella Spiralis Infection
Infection With Trichinella	Trichinelliasis
Trichinella Spiralis Infestation

Milk Allergy

Milk Allergic Reaction	Milk Hypersensitivity
Allergy Milk

Conjunctival Disease

Conjunctival Diseases

Conjunctival Disorder

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Integumentary System Disease

Adult-Onset Severe Asthma

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Mite Infestation

Mite Infestations	Acariasis
Infestation By Mites Nos

Ichthyosis Vulgaris

Ichthyosis Simplex	Dominant Congenital Ichthyosiform Erythroderma
Common Ichthyosis	Fish Scale Disease
VI	Ichthyoses
Congenital Ichthyosis

Paranasal Sinus Disease

Paranasal Sinus Diseases

Disorder Of Nasal Sinus

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis	Chronic Ethmoid Sinusitis
Ethmoidal Sinusitis - Chronic

Upper Respiratory Tract Disease

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150207	RBN-3143	Inhibitor	99.24%	Unkown
HY-163289	TSLP binder-1		/	Unkown
HY-RS15153	TSLP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990748	Lunsekimig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSLP	MGD	MGI:1855696
Canis familiaris	TSLP	VGNC	VGNC:53251
Macaca mulatta	TSLP	VGNC	VGNC:79871
Rattus norvegicus	TSLP	RGD	RGD:1586479
Felis catus	TSLP	VGNC	VGNC:66621
Macaca fascicularis	TSLP	NCBI	NCBI:102119254
Others	TSLP	NCBI