1. Gene
  2. TSLP - thymic stromal lymphopoietin Gene

TSLP - thymic stromal lymphopoietin Gene

Homo sapiens
Gene ID: 85480 | Gene type: protein coding

About TSLP

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,070,062-111,078,026 (from NCBI)

This gene has 3 transcripts (splice variants) and 65 orthologues. Broad expression in gall bladder (RPKM 3.6), liver (RPKM 3.0) and 15 other tissues.

Summary

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying Antibacterial and Antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]

TSLP Products(2)

mRNA Protein Name
NM_033035.5 NP_149024.1 thymic stromal lymphopoietin isoform 1 precursor
NM_138551.5 NP_612561.2 thymic stromal lymphopoietin isoform 2

TSLP Protein Structure

TSLP

TSLP: Thymic stromal lymphopoietin (29 - 153)

  • 0
  • 100
  • 159 a.a.
Protein Preferred Names Protein Names

thymic stromal lymphopoietin

Recombinant TSLP Proteins

Cat. No. Product Name Accession Purity
HY-P7057 TSLP Protein, Human Q969D9-1 (Y29-Q159) ≥95%
HY-P70818 TSLP Protein, Human (HEK293, His) Q969D9-1 (Y29-Q159) ≥95%
HY-P78224 TSLP Protein, Human (Biotinylated, HEK293, His-Avi) Q969D9-1 (Y29-Q159) ≥95%
HY-P78225 TSLP Protein, Human (Biotinylated, R127A, R130A, HEK293, His-Avi) Q969D9-1 (Y29-Q159, R127A, R130A) ≥95%
HY-P78532 TSLP Protein, Human (HEK293, His-Avi) Q969D9-1 (Y29-Q159) ≥95%
HY-P78533 TSLP Protein, Human (R127A, R130A, HEK293, His-Avi) Q969D9-1 (Y29-Q159, R127A, R130A) ≥95%
HY-P78658 TSLP Protein, Human (R127A, R130A, HEK293, His) Q969D9-1 (Y29-Q159, R127A, R130A) ≥95%
HY-P78659 TSLP Protein, Human (R127A, R130A, HEK293, mFc) Q969D9-1 (Y29-Q159, R127A, R130A) ≥95%
HY-P700601 TSLP Protein, Human (HEK293, His-Myc) Q969D9-1 (Y29-Q159) ≥95%

Related Diseases

Diseases Alias
Cryoglobulinemia

Cryoimmunoglobulinaemia

Allergic Asthma

Atopic Asthma

Extrinsic Asthma

Extrinsic Asthma With Acute Exacerbation

Extrinsic Asthma With Status Asthmaticus

Asthma Allergic

Atopic Asthma, Susceptibility To

Ige-Mediated Allergic Asthma

Allergen-Induced Asthma

Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma

Allergic Asthma Nos

Catarrh With Asthma

Allergic Bronchitis Nos

Extrinsic Allergic Asthma

Predominantly Allergic Asthma With Stated Status Asthmaticus

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis

Dense Deposit Disease

Membranoproliferative Glomerulonephritis Type 2

Primary Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis, Type Ii

Glomerulonephritis, Membranoproliferative

Chronic Glomerulonephritis, Lobular

Lobular Glomerulonephritis

Ddd

Glomerulonephritis Membranoproliferative Type 2

Mpgn 2

Membranoproliferative Glomerulonephritis Type Ii

Mesangiocapillary Glomerulonephritis Type 2

Mpgn

Primary Mpgn

Glomerulonephritis Membranoproliferative

Membranoproliferative Glomerulonephritis, Type Ii

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Cryoglobulinemia, Familial Mixed

Cryoglobulinemic Vasculitis

Essential Mixed Cryoglobulinemia

Mixed Cryoglobulinemia

Essential Cryoglobulinemia

Primary Cryoglobulinemia

Meltzer Syndrome

Familial Mixed Cryoglobulinemia

Esophagitis

Acute Esophagitis

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

T2-Low Asthma

Type 2 Low Endotype

Respiratory Allergy

Airway Allergy

Chronic Asthma
Eczema Herpeticum

Herpes Simplex Dermatitis

Herpes Simplex Eyelid Dermatitis

Kaposi Varicelliform Eruption

Herpes Simplex Dermatitis Of Eyelid

Herpes Simplex Virus Dermatitis

Herpes Simplex Virus Eyelid Dermatitis

Nasal Cavity Disease

Disorder Of Nasal Cavity

Rhinitis

Runny Nose

T2-High Asthma

Type 2 High Endotype

Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose

Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency

SCIDX1

XSCID

Scidx

X-Linked Scid

X-Scid

Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative

Scid, X-Linked

Immunodeficiency 4

Imd4

Gamma Chain Deficiency

Scid-X1

X-Linked Combined Immunodeficiency Diseases

Thymic Epithelial Hypoplasia

Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency

Severe Combined Immunodeficiency T- B+, X-Linked

Il2rg Scid, T- B+ Nk-

T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency

T-B+ Scid Due To Gamma Chain Deficiency

T-B+ Severe Combined Immunodeficiency, X-Linked

Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative

Agammaglobulinemia Swiss Type

Scid X-Linked

Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative

Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee

Legume Allergy

Fabaceae Allergy

Acute Asthma
Occupational Asthma
Environmental Induced Asthma

Irritant Asthma

Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm

Intrinsic Asthma

Non-Atopic Asthma

Neurodermatitis
Peanut Allergy

Allergy To Peanuts

Peanut Allergic Reaction

Allergies Peanut

Peanut Hypersensitivity

Fruit Allergy

Allergy To Fruit

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos

Chronic Conjunctivitis
Dermatitis, Atopic, 3

ATOD3

Dermatitis, Atopic, Susceptibility To, 3

Atopic Dermatitis 3

Dermatitis, Atopic, With Asthma

Dermatitis, Atopic 3

Atopic Dermatitis With Asthma

Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Intermittent Asthma
Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation

Allergic Conjunctivitis

Conjunctivitis Allergic

Conjunctivitis, Allergic

Allergen-Induced Conjunctivitis

Seasonal Allergic Conjunctivitis

Perennial Allergic Conjunctivitis

Spring Conjunctivitis

Acute Allergic Conjunctivitis

Goat Milk Allergy

Capra Hircus Milk Allergy

Glomerulonephritis

Bright'S Disease

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Egg Allergy

Allergy To Eggs

Allergies Egg

Egg Hypersensitivity

Eosinophilic Gastritis

Eosinophilic Enteropathy

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Food Allergy

Food Hypersensitivity

Food Allergies

Allergy Food

Food Allergen-Induced Hypersensitivity

Irritant Dermatitis

Irritant Contact Dermatitis

Primary Irritant Dermatitis

Dermatitis, Irritant

Contact Dermatitis, Irritant

Irritant Contact Eczema

Icd - [Irritant Contact Dermatitis]

Irritant Contact Dermatitis, Unspecified Cause

Non-Allergic Contact Dermatitis

Irritant Contact Eczema Due To Wet Work

Irritant Contact Dermatitis Due To Detergents

Irritant Contact Eczema Due To Solvents

Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

Irritant Contact Eczema Due To Cosmetics Or Emollients

Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

Irritant Contact Eczema Due To Foods

Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

Irritant Contact Eczema Due To Saliva

Irritant Contact Eczema Due To Incontinence

Incontinence-Associated Dermatitis

Persistent Severe Asthma
Near-Fatal Asthma
Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax

PSP

Pneumothorax

Trichinosis

Trichinellosis

Human Trichinellosis

Trichiniasis

Trichinella Spiralis Infection

Infection With Trichinella

Trichinelliasis

Trichinella Spiralis Infestation

Milk Allergy

Milk Allergic Reaction

Milk Hypersensitivity

Allergy Milk

Conjunctival Disease

Conjunctival Diseases

Conjunctival Disorder

Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Integumentary System Disease
Adult-Onset Severe Asthma
Dermatitis, Atopic, 5

ATOD5

Atopic Dermatitis 5

Dermatitis, Atopic, Susceptibility To, 5

Dermatitis, Atopic 5

Mite Infestation

Mite Infestations

Acariasis

Infestation By Mites Nos

Ichthyosis Vulgaris

Ichthyosis Simplex

Dominant Congenital Ichthyosiform Erythroderma

Common Ichthyosis

Fish Scale Disease

VI

Ichthyoses

Congenital Ichthyosis

Paranasal Sinus Disease

Paranasal Sinus Diseases

Disorder Of Nasal Sinus

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis

Chronic Ethmoid Sinusitis

Ethmoidal Sinusitis - Chronic

Upper Respiratory Tract Disease
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus TSLP MGD MGI:1855696
Canis familiaris TSLP VGNC VGNC:53251
Macaca mulatta TSLP VGNC VGNC:79871
Rattus norvegicus TSLP RGD RGD:1586479
Felis catus TSLP VGNC VGNC:66621
Macaca fascicularis TSLP NCBI NCBI:102119254
Others TSLP NCBI