KHSRP - KH-type splicing regulatory protein Gene

Homo sapiens

Also known as p75; FBP2; KSRP; FUBP2

Gene ID: 8570 | Gene type: protein coding

About KHSRP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,413,102-6,424,811 (from NCBI)

This gene has 12 transcripts (splice variants), 244 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues.

Summary

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

KHSRP Products(3)

mRNA	Protein	Name
NM_001366299.1	NP_001353228.1	far upstream element-binding protein 2 isoform 2
NM_001366300.1	NP_001353229.1	far upstream element-binding protein 2 isoform 3
NM_003685.3	NP_003676.2	far upstream element-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	16126846	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16126846	GOA
enables protein folding chaperone	EXP EXP: Inferred from Experiment	19198587	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	16126846	GOA
involved in 3'-UTR-mediated mRNA destabilization	IMP IMP: Inferred from mutant phenotype	28275056	GOA
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	16126846	GOA
involved in miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	27478153	GOA
involved in negative regulation of low-density lipoprotein particle clearance	IGI IGI: Inferred from genetic interaction	26523989	GOA
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	16126846	GOA
involved in positive regulation of mRNA catabolic process	IDA IDA: Inferred from direct assay	16126846	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	16126846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KHSRP Protein Structure

KH_1

DUF1897

0
200
400
600
711 a.a.

Protein Preferred Names

Protein Names

far upstream element-binding protein 2

FUSE-binding protein 2

KHSRP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	KHSRP	Q92945	Ywhaz	Mus musculus	P63101	NMR	19198587
Cross	KHSRP	Q92945	Ywhaz	Mus musculus	P63101	Y2H	17437629

Cross: Cross-species interaction Intra: Intraspecies interaction

KHSRP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82398	KHSRP Antibody (YA2143)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124648	SMN-C2		98.85%	Unkown
HY-RS07242	KHSRP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KHSRP	VGNC	VGNC:42340
Mus musculus	KHSRP	MGD	MGI:1336214
Macaca mulatta	KHSRP	VGNC	VGNC:74015
Bos taurus	KHSRP	VGNC	VGNC:30545
Felis catus	KHSRP	VGNC	VGNC:67938
Rattus norvegicus	KHSRP	RGD	RGD:621828

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