PLPP2 - phospholipid phosphatase 2 Gene

Homo sapiens

Also known as LPP2; PAP-2c; PAP2-g; PPAP2C

Gene ID: 8612 | Gene type: protein coding

About PLPP2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:281,043-291,403 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 9 paralogues. Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is similar to phosphatidic Acid Phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

PLPP2 Products(3)

mRNA	Protein	Name
NM_003712.4	NP_003703.1	phospholipid phosphatase 2 isoform 1
NM_177526.3	NP_803545.1	phospholipid phosphatase 2 isoform 2
NM_177543.3	NP_808211.1	phospholipid phosphatase 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sphingosine-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	9705349	GOA
involved in phospholipid dephosphorylation	IDA IDA: Inferred from direct assay	9705349	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	9705349	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	9705349	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	16467304	GOA
located in early endosome	IDA IDA: Inferred from direct assay	16467304	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16467304	GOA
located in membrane	IDA IDA: Inferred from direct assay	9705349	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16467304	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP2 Protein Structure

PAP2

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

phospholipid phosphatase 2

PAP2-gamma

PLPP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLPP2	O43688	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	PLPP2	O43688	TRAM1L1	Homo sapiens	Q8N609	Validated Y2H	32296183
Intra	PLPP2	O43688	VSTM1	Homo sapiens	Q6UX27-3	Validated Y2H	32296183
Intra	PLPP2	O43688	NSG1	Homo sapiens	P42857	Validated Y2H	32296183
Intra	PLPP2	O43688	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	PLPP2	O43688	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myxosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10735	PLPP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLPP2	RGD	RGD:628893
Mus musculus	PLPP2	MGD	MGI:1354945
Felis catus	PLPP2	VGNC	VGNC:80656
Canis familiaris	PLPP2	VGNC	VGNC:44706
Bos taurus	PLPP2	VGNC	VGNC:33045

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