2. Gene
  3. NSG1 - neuronal vesicle trafficking associated 1 Gene

NSG1 - neuronal vesicle trafficking associated 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P21; D4S234; NEEP21; D4S234E

Gene ID: 27065 | Gene type: protein coding

About NSG1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:4,386,532-4,419,058 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 2 paralogues. Biased expression in skin (RPKM 37.1), prostate (RPKM 21.2) and 12 other tissues.

Summary

Predicted to enable clathrin LIGHT chain binding activity. Involved in apoptotic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

NSG1 Products(6)

mRNA Protein Name
NM_001040101.2 NP_001035190.1 neuronal vesicle trafficking-associated protein 1 isoform a
NM_001287763.2 NP_001274692.1 neuronal vesicle trafficking-associated protein 1 isoform a
NM_001287764.2 NP_001274693.1 neuronal vesicle trafficking-associated protein 1 isoform b
NM_001382227.1 NP_001369156.1 neuronal vesicle trafficking-associated protein 1 isoform c
NM_001382228.1 NP_001369157.1 neuronal vesicle trafficking-associated protein 1 isoform d
NM_014392.5 NP_055207.1 neuronal vesicle trafficking-associated protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20599942 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
20599942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSG1 Protein Structure

Calcyon

Calcyon: D1 dopamine receptor-interacting protein (calcyon) (1 - 184)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

neuronal vesicle trafficking-associated protein 1

brain neuron cytoplasmic protein 1

NSG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NSG1 P42857 BSCL2 Homo sapiens Q96G97-4
Y2H Prey Pooling
25416956
Intra NSG1 P42857 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra NSG1 P42857 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra NSG1 P42857 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra NSG1 P42857 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra NSG1 P42857 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra NSG1 P42857 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra NSG1 P42857 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra NSG1 P42857 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra NSG1 P42857 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra NSG1 P42857 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra NSG1 P42857 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra NSG1 P42857 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra NSG1 P42857 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra NSG1 P42857 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra NSG1 P42857 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra NSG1 P42857 FIMP Homo sapiens Q96LL3
Y2H Prey Pooling
32296183
Intra NSG1 P42857 FIMP Homo sapiens Q96LL3
Y2H Array
32296183
Intra NSG1 P42857 FIMP Homo sapiens Q96LL3
Validated Y2H
32296183
Intra NSG1 P42857 TMEM207 Homo sapiens Q6UWW9
Validated Y2H
32296183
Intra NSG1 P42857 TMEM207 Homo sapiens Q6UWW9
Y2H Array
32296183
Intra NSG1 P42857 TMEM207 Homo sapiens Q6UWW9
Y2H Prey Pooling
32296183
Intra NSG1 P42857 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra NSG1 P42857 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra NSG1 P42857 TM4SF18 Homo sapiens Q96CE8
Validated Y2H
32296183
Intra NSG1 P42857 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
Intra NSG1 P42857 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
Intra NSG1 P42857 FCGR2A Homo sapiens P12318-2
Y2H Prey Pooling
32296183
Intra NSG1 P42857 FCGR2A Homo sapiens P12318-2
Y2H Array
32296183
Intra NSG1 P42857 SPACA1 Homo sapiens Q9HBV2
Validated Y2H
32296183
Intra NSG1 P42857 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra NSG1 P42857 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra NSG1 P42857 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra NSG1 P42857 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra NSG1 P42857 BTN2A1 Homo sapiens Q7KYR7-4
Validated Y2H
32296183
Intra NSG1 P42857 BTN2A1 Homo sapiens Q7KYR7-4
Y2H Array
32296183
Intra NSG1 P42857 BTN2A1 Homo sapiens Q7KYR7-4
Y2H Prey Pooling
32296183
Intra NSG1 P42857 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra NSG1 P42857 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra NSG1 P42857 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra NSG1 P42857 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra NSG1 P42857 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra NSG1 P42857 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra NSG1 P42857 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra NSG1 P42857 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra NSG1 P42857 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra NSG1 P42857 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra NSG1 P42857 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra NSG1 P42857 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra NSG1 P42857 GPA33 Homo sapiens Q99795
Y2H Prey Pooling
32296183
Intra NSG1 P42857 GPA33 Homo sapiens Q99795
Validated Y2H
32296183
Intra NSG1 P42857 GPA33 Homo sapiens Q99795
Y2H Array
32296183
Intra NSG1 P42857 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra NSG1 P42857 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra NSG1 P42857 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra NSG1 P42857 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra NSG1 P42857 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra NSG1 P42857 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra NSG1 P42857 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra NSG1 P42857 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra NSG1 P42857 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra NSG1 P42857 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra NSG1 P42857 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra NSG1 P42857 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra NSG1 P42857 PLPP2 Homo sapiens O43688
Y2H Prey Pooling
32296183
Intra NSG1 P42857 PLPP2 Homo sapiens O43688
Y2H Array
32296183
Intra NSG1 P42857 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra NSG1 P42857 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra NSG1 P42857 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra NSG1 P42857 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra NSG1 P42857 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra NSG1 P42857 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra NSG1 P42857 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra NSG1 P42857 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra NSG1 P42857 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra NSG1 P42857 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra NSG1 P42857 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra NSG1 P42857 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra NSG1 P42857 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra NSG1 P42857 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra NSG1 P42857 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome

SCDO1

Vertebral Anomalies

Spondylothoracic Dysplasia

Costovertebral Dysplasia

Spondylothoracic Dysostosis

Spondylocostal Dysostosis 1

Autosomal Recessive Spondylocostal Dysostosis 1

Spondylocostal Dysostosis, Autosomal Recessive, 1

Doid:0112365

Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09593 NSG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NSG1 RGD RGD:2222
Felis catus NSG1 VGNC VGNC:78539
Bos taurus NSG1 VGNC VGNC:32276
Macaca mulatta NSG1 VGNC VGNC:75433
Canis familiaris NSG1 VGNC VGNC:43985
Mus musculus NSG1 MGD MGI:109149