PLPP3 - phospholipid phosphatase 3 Gene

Homo sapiens

Also known as LPP3; VCIP; Dri42; PAP2B; PPAP2B

Gene ID: 8613 | Gene type: protein coding

About PLPP3

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,494,761-56,579,563 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PLPP3 Products(1)

mRNA	Protein	Name
NM_003713.5	NP_003704.3	phospholipid phosphatase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	12660161	GOA
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	9305923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20123964	GOA
enables sphingosine-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9305923	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12660161	GOA
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in homotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	20123964	GOA
acts upstream of integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	12660161	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20123964	GOA
involved in phospholipid dephosphorylation	IDA IDA: Inferred from direct assay	9305923	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20123964	GOA
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20123964	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	20123964	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	20123964	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23591818	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in wound healing	IMP IMP: Inferred from mutant phenotype	20123964	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23591818	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	14527693	GOA
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	23591818	GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	23591818	GOA
located in membrane	IDA IDA: Inferred from direct assay	9305923	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	17005594	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	23591818	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP3 Protein Structure

PAP2

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

phospholipid phosphatase 3

PAP2 beta

PLPP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLPP3	O14495	CTNND1	Homo sapiens	O60716	Pull Down	20123964
Intra	PLPP3	O14495	CTNND1	Homo sapiens	O60716	Confocal	20123964
Intra	PLPP3	O14495	CTNND1	Homo sapiens	O60716	Anti Tag CoIP	20123964
Intra	PLPP3	O14495	CTNND1	Homo sapiens	O60716	Anti Bait CoIP	20123964

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10736	PLPP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLPP3	VGNC	VGNC:100040
Rattus norvegicus	PLPP3	RGD	RGD:620454
Mus musculus	PLPP3	MGD	MGI:1915166
Canis familiaris	PLPP3	VGNC	VGNC:44707
Bos taurus	PLPP3	VGNC	VGNC:33046

Name
Email *

	Sorry, but the email address you supplied was invalid.