PLPP3 - phospholipid phosphatase 3 Gene

Homo sapiens

Also known as LPP3; VCIP; Dri42; PAP2B; PPAP2B

Gene ID: 8613 | Gene type: protein coding

About PLPP3

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,494,761-56,579,563 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PLPP3 Products(1)

mRNA	Protein	Name
NM_003713.5	NP_003704.3	phospholipid phosphatase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9705349	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	12660161	GOA
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	9305923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20123964	GOA
enables sphingosine-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	9305923	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12660161	GOA
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in homotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	20123964	GOA
acts upstream of integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	12660161	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20123964	GOA
involved in phospholipid dephosphorylation	IDA IDA: Inferred from direct assay	9305923	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20123964	GOA
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20123964	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	20123964	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	20123964	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23591818	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	9305923	GOA
involved in wound healing	IMP IMP: Inferred from mutant phenotype	20123964	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23591818	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	14527693	GOA
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	23591818	GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	23591818	GOA
located in membrane	IDA IDA: Inferred from direct assay	9305923	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	17005594	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	23591818	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP3 Protein Structure

PAP2

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

phospholipid phosphatase 3

PAP2 beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10736	PLPP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLPP3	VGNC	VGNC:100040
Rattus norvegicus	PLPP3	RGD	RGD:620454
Mus musculus	PLPP3	MGD	MGI:1915166
Canis familiaris	PLPP3	VGNC	VGNC:44707
Bos taurus	PLPP3	VGNC	VGNC:33046

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