2. Gene
  3. USO1 - USO1 vesicle transport factor Gene

USO1 - USO1 vesicle transport factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TAP; VDP; P115

Gene ID: 8615 | Gene type: protein coding

About USO1

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,724,577-75,814,286 (from NCBI)

This gene has 4 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 38.1), testis (RPKM 30.9) and 25 other tissues.

Summary

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

USO1 Products(2)

mRNA Protein Name
NM_001290049.2 NP_001276978.1 general vesicular transport factor p115 isoform 1
NM_003715.4 NP_003706.2 general vesicular transport factor p115 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USO1 Protein Structure

Uso1_p115_head

Uso1_p115_head: Uso1 / p115 like vesicle tethering protein, head region (329 - 613)

Uso1_p115_C

Uso1_p115_C: Uso1 / p115 like vesicle tethering protein, C terminal region (812 - 937)

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  • 947 a.a.
Protein Preferred Names Protein Names

general vesicular transport factor p115

USO1 vesicle docking protein homolog

USO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
USO1 O60763 XPO7 Homo sapiens Q9UIA9
Y2H Array
25416956
Intra
USO1 O60763 DUSP12 Homo sapiens Q9UNI6
Y2H Array
25416956
Intra
USO1 O60763 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
25416956
Intra
USO1 O60763 PHYKPL Homo sapiens Q8IUZ5
Y2H Prey Pooling
25416956
Intra
USO1 O60763 AKAP9 Homo sapiens Q99996-2
Y2H Array
25416956
Intra
USO1 O60763 AKAP9 Homo sapiens Q99996-2
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

USO1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82644 USO1 Antibody (YA2389) WB, IP Mouse

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15519 USO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USO1 VGNC VGNC:48176
Bos taurus USO1 VGNC VGNC:36708
Macaca mulatta USO1 VGNC VGNC:79896
Rattus norvegicus USO1 RGD RGD:621604
Felis catus USO1 VGNC VGNC:66863
Mus musculus USO1 MGD MGI:1929095