2. Gene
  3. HYAL2 - hyaluronidase 2 Gene

HYAL2 - hyaluronidase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LUCA2

Gene ID: 8692 | Gene type: protein coding

About HYAL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,317,808-50,322,745 (from NCBI)

This gene has 10 transcripts (splice variants), 294 orthologues, 4 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 78.9), lung (RPKM 35.1) and 20 other tissues.

Summary

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

HYAL2 Products(2)

mRNA Protein Name
NM_003773.5 NP_003764.3 hyaluronidase-2 precursor
NM_033158.5 NP_149348.2 hyaluronidase-2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
19366691 GOA
enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
12676986 GOA
enables hyaluronoglucuronidase activity IDA
IDA: Inferred from direct assay
21699545 GOA
NOT enables hyalurononglucosaminidase activity IDA
IDA: Inferred from direct assay
11296287 GOA
enables hyalurononglucosaminidase activity IDA
IDA: Inferred from direct assay
9712871 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12676986 GOA
enables receptor signaling protein tyrosine kinase inhibitor activity IDA
IDA: Inferred from direct assay
12676986 GOA
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12676986 GOA
enables virus receptor activity IDA
IDA: Inferred from direct assay
11296287 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cartilage development IEP
IEP: Inferred from expression pattern
11944887 GOA
involved in cellular response to UV-B IDA
IDA: Inferred from direct assay
21699545 GOA
involved in cellular response to fibroblast growth factor stimulus IDA
IDA: Inferred from direct assay
19577615 GOA
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
18390475 GOA
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
19366691 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18390475 GOA
involved in fusion of virus membrane with host plasma membrane IDA
IDA: Inferred from direct assay
11296287 GOA
involved in glycosaminoglycan catabolic process IDA
IDA: Inferred from direct assay
9712871 GOA
involved in hyaluronan catabolic process IDA
IDA: Inferred from direct assay
17170110 GOA
involved in monocyte activation IDA
IDA: Inferred from direct assay
19443707 GOA
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
12676986 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
18725949 GOA
involved in negative regulation of fibroblast migration IDA
IDA: Inferred from direct assay
19577615 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
12676986 GOA
involved in negative regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
12676986 GOA
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
19443707 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
19443707 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
19443707 GOA
involved in response to antibiotic IEP
IEP: Inferred from expression pattern
11944887 GOA
involved in response to reactive oxygen species IDA
IDA: Inferred from direct assay
20554532 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
11296287 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20554532 GOA
located in cell surface IDA
IDA: Inferred from direct assay
17170110 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17170110 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
16600643 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19366691 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
19366691 GOA
colocalizes with external side of plasma membrane IDA
IDA: Inferred from direct assay
19443707 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11296287 GOA
located in lysosome IDA
IDA: Inferred from direct assay
9712871 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
21740893 GOA
located in microvillus IDA
IDA: Inferred from direct assay
19366691 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16600643 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18390475 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HYAL2 Protein Structure

Glyco_hydro_56

Glyco_hydro_56: Hyaluronidase (28 - 362)

  • 0
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  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

hyaluronidase-2

PH-20 homolog

HYAL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HYAL2 Q12891 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra HYAL2 Q12891 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra HYAL2 Q12891 PSEN1 Homo sapiens P49768-2
Validated Y2H
32814053
Intra HYAL2 Q12891 PSEN1 Homo sapiens P49768-2
Y2H Array
32814053
Intra HYAL2 Q12891 PSEN1 Homo sapiens P49768-2
Y2H Pooling
32814053
Intra HYAL2 Q12891 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra HYAL2 Q12891 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra HYAL2 Q12891 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra HYAL2 Q12891 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra HYAL2 Q12891 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra HYAL2 Q12891 APP Homo sapiens P05067-2
Y2H Pooling
32814053
Intra HYAL2 Q12891 APP Homo sapiens P05067-2
Validated Y2H
32814053
Intra HYAL2 Q12891 APP Homo sapiens P05067-2
Y2H Array
32814053
Intra HYAL2 Q12891 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra HYAL2 Q12891 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra HYAL2 Q12891 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra HYAL2 Q12891 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra HYAL2 Q12891 PON2 Homo sapiens Q15165
Anti Tag CoIP
33961781
Intra HYAL2 Q12891 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
Intra HYAL2 Q12891 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra HYAL2 Q12891 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra HYAL2 Q12891 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra HYAL2 Q12891 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra HYAL2 Q12891 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra HYAL2 Q12891 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra HYAL2 Q12891 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra HYAL2 Q12891 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
25416956
Intra HYAL2 Q12891 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra HYAL2 Q12891 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra HYAL2 Q12891 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome

Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Deafness Syndrome

Hyaluronidase 2 Deficiency
Cor Triatriatum

Triatrial Heart
Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix

Hyaluronidase Deficiency

MPS9

Mps Ix

Mucopolysaccharidosis Ix

Mpsix

Mucopolysaccharidosis Type 9

Mucopolysaccharidosis 9
Bronchiolo-Alveolar Adenocarcinoma

Bronchioloalveolar Carcinoma

Bronchioalveolar Lung Carcinoma

Minimally Invasive Lung Adenocarcinoma

Carcinoma Bronchioloalveolar

Adenocarcinoma, Bronchiolo-Alveolar

Bronchioloalveolar Adenocarcinoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06496 HYAL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HYAL2 RGD RGD:620321
Bos taurus HYAL2 VGNC VGNC:30011
Mus musculus HYAL2 MGD MGI:1196334
Canis familiaris HYAL2 VGNC VGNC:41843
Felis catus HYAL2 VGNC VGNC:67679
Macaca mulatta HYAL2 VGNC VGNC:73548
Others HYAL2 NCBI