ADAM19 - ADAM metallopeptidase domain 19 Gene

Homo sapiens

Also known as MLTNB; FKSG34; MADDAM

Gene ID: 8728 | Gene type: protein coding

About ADAM19

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,477,304-157,575,775 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 12.3), appendix (RPKM 11.1) and 18 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as Cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

ADAM19 Products(1)

mRNA	Protein	Name
NM_033274.5	NP_150377.1	disintegrin and metalloproteinase domain-containing protein 19 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	11162584	GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	17112471	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11162584	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	17112471	GOA
involved in placenta development	IEP IEP: Inferred from expression pattern	19727588	GOA
involved in positive regulation of cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	19727588	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19727588	GOA
involved in protein processing	IMP IMP: Inferred from mutant phenotype	17112471	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19727588	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM19 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
800
955 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 19

a disintegrin and metalloproteinase domain 19 (meltrin beta)

ADAM19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADAM19	Q9H013	SH3PXD2A	Homo sapiens	Q5TCZ1	Phage Display	25825872
Intra	ADAM19	Q9H013	SH3PXD2A	Homo sapiens	Q5TCZ1	Anti Tag CoIP	33961781
Intra	ADAM19	Q9H013	TSPOAP1	Homo sapiens	O95153	Peptide Array	25825872
Intra	ADAM19	Q9H013	TSPOAP1	Homo sapiens	O95153	Phage Display	25825872
Intra	ADAM19	Q9H013	EPS8L1	Homo sapiens	Q8TE68	Peptide Array	25825872
Intra	ADAM19	Q9H013	EPS8L1	Homo sapiens	Q8TE68	Phage Display	25825872

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi Renotubular Syndrome 1

Renal Fanconi Syndrome	Adult Fanconi Syndrome
FRTS1	Fanconi Renotubular Syndrome
Frts	Rfs
Fanconi Syndrome Without Cystinosis	Luder-Sheldon Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00275	ADAM19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADAM19	VGNC	VGNC:37577
Rattus norvegicus	ADAM19	RGD	RGD:1585017
Mus musculus	ADAM19	MGD	MGI:105377
Felis catus	ADAM19	VGNC	VGNC:59578
Bos taurus	ADAM19	VGNC	VGNC:25608
Macaca mulatta	ADAM19	VGNC	VGNC:69479
Others	ADAM19	NCBI

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