SUCLG2 - succinate-CoA ligase GDP-forming subunit beta Gene

Homo sapiens

Also known as G-SCS; GBETA; GTPSCS

Gene ID: 8801 | Gene type: protein coding

About SUCLG2

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,360,460-67,654,612 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 21.2), kidney (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

SUCLG2 Products(2)

mRNA	Protein	Name
NM_001177599.2	NP_001171070.1	succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor
NM_003848.4	NP_003839.2	succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24606901	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of succinate-CoA ligase complex (GDP-forming)	IPI IPI: Inferred from physical interaction	32627745	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUCLG2 Protein Structure

ATP-grasp_2

Ligase_CoA

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

GTP-specific succinyl-CoA synthetase beta subunit

SUCLG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUCLG2	Q96I99	SUCLG1	Homo sapiens	P53597	Anti Tag CoIP	28514442
Intra	SUCLG2	Q96I99	SUCLG1	Homo sapiens	P53597	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Vitreous Abscess

Uvulitis

Acute Uvulitis

Ocular Albinism

Albinism, Ocular	Oa
Xloa	Albinism Ocular

Panophthalmitis

Lemierre'S Syndrome

Lemierre Syndrome	Lemierre Postanginal Sepsis
Necrobacillosis	Postanginal Sepsis Secondary To Orophyngeal Infection
Septic Phlebitis Of The Internal Jugular Vein	Fusobacterium Infections
Acute Sore Throat	Human Necrobacillosis
Postanginal Sepsis	Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein

Necrotizing Ulcerative Gingivitis

Acute Necrotizing Ulcerative Gingivitis	Anug
Vincent Angina	Vincent'S Disease
Acute Necrotising Ulcerative Gingivitis	Acute Necrotising Ulcerative Gingivostomatitis
Acute Necrotizing Ulcerative Gingivostomatitis	Acute Ulceromembranous Gingivitis
Angina - Vincents	Early Acute Necrotising Gingivitis
Trench Mouth	Vincent'S Angina
Vincent'S Angina - Pharyngitis	Vincent'S Infection, Any Site
Acute Membranous Gingivitis	Fusospirillary Gingivitis
Fusospirillosis	Phagedenic Gingivitis
Vincent'S Gingivitis	Vincent'S Infection
Vincent'S Stomatitis	Gingivitis, Necrotizing Ulcerative

Astigmatism

Purulent Endophthalmitis

Periocular Infection	Acute Endophthalmitis
Endophthalmia	Eye Infestation Nos
Intraocular Infection	Eye Infection Nos

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14002	SUCLG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUCLG2	RGD	RGD:1305008
Canis familiaris	SUCLG2	VGNC	VGNC:46967
Bos taurus	SUCLG2	VGNC	VGNC:35457
Macaca mulatta	SUCLG2	VGNC	VGNC:103873
Mus musculus	SUCLG2	MGD	MGI:1306824
Felis catus	SUCLG2	VGNC	VGNC:65826

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