GALR2 - galanin receptor 2 Gene

Homo sapiens

Also known as GAL2-R; GALNR2; GALR-2

Gene ID: 8811 | Gene type: protein coding

About GALR2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,071,962-76,077,537 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues and 23 paralogues. Low expression observed in reference dataset.

Summary

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of Galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the Galanin peptide. The primary signaling mechanism for GALR2 is through the Phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

GALR2 Products(1)

mRNA	Protein	Name
NM_003857.4	NP_003848.1	galanin receptor type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables galanin receptor activity	IDA IDA: Inferred from direct assay	9832121	GOA
enables peptide hormone binding	IDA IDA: Inferred from direct assay	24517231	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	9832121	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in galanin-activated signaling pathway	IDA IDA: Inferred from direct assay	9832121	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9832121	GOA
involved in positive regulation of large conductance calcium-activated potassium channel activity	IMP IMP: Inferred from mutant phenotype	24602615	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24517231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALR2 Protein Structure

7tm_1

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

galanin receptor type 2

GALR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GALR2	O43603	P22466-PRO_0000010449	Homo sapiens	P22466-PRO_0000010449	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arboleda-Tham Syndrome

Kat6a Syndrome	Autosomal Dominant Intellectual Disability-Craniofacial Anomalies-Cardiac Defects Syndrome
ARTHS	Mrd32
Mental Retardation, Autosomal Dominant 32, Formerly	Mrd32, Formerly
Autosomal Dominant Mental Retardation 32	Autosomal Dominant Non-Syndromic Intellectual Disability 32
Arboleda-Tham

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1127	Galanin (1-30), human	Agonist	99.90%	Unkown
HY-P1130	M871	Antagonist	99.80%	Unkown
HY-RS05265	GALR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123671	CYM2503	Modulator	96.01%	Unkown
HY-P1129	AR-M1896	Agonist	/	Unkown
HY-P5064	Galanin-Like Peptide (porcine)	Agonist	/	Unkown
HY-P5894	human GALP (3-32)	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GALR2	VGNC	VGNC:29240
Rattus norvegicus	GALR2	RGD	RGD:2657
Mus musculus	GALR2	MGD	MGI:1337018
Canis familiaris	GALR2	VGNC	VGNC:41101
Macaca mulatta	GALR2	VGNC	VGNC:104602

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