ALKBH1 - alkB homolog 1, histone H2A dioxygenase Gene

Homo sapiens

Also known as ABH; ABH1; alkB; hABH; ALKBH

Gene ID: 8846 | Gene type: protein coding

About ALKBH1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,672,404-77,708,023 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 4.0), thyroid (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]

ALKBH1 Products(1)

mRNA	Protein	Name
NM_006020.3	NP_006011.2	nucleic acid dioxygenase ALKBH1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2-oxoglutarate-dependent dioxygenase activity	IDA IDA: Inferred from direct assay	27497299	GOA
enables broad specificity oxidative DNA demethylase activity	IDA IDA: Inferred from direct assay	18603530	GOA
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	19959401	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	18603530	GOA
enables oxidative RNA demethylase activity	IDA IDA: Inferred from direct assay	18603530	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	27497299	GOA
enables tRNA demethylase activity	IDA IDA: Inferred from direct assay	27745969	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair	IDA IDA: Inferred from direct assay	19959401	GOA
involved in oxidative RNA demethylation	IDA IDA: Inferred from direct assay	31188562	GOA
involved in positive regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	30017583	GOA
involved in regulation of mitochondrial translation	IMP IMP: Inferred from mutant phenotype	27497299	GOA
involved in regulation of translational elongation	IMP IMP: Inferred from mutant phenotype	27745969	GOA
involved in regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	27745969	GOA
involved in regulation of translational initiation by tRNA modification	IDA IDA: Inferred from direct assay	27745969	GOA
involved in tRNA wobble cytosine modification	IDA IDA: Inferred from direct assay	27497299	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	18603530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH1 Protein Structure

2OG-FeII_Oxy_2

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

nucleic acid dioxygenase ALKBH1

DNA 6mA demethylase

Related Diseases

Diseases

Alias

Plantar Fasciitis

Fasciitis, Plantar

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163385	ALKBH1-IN-1		98.88%	Unkown
HY-158998	ALKBH1-IN-2		99.16%	Unkown
HY-168044	ALKBH1-IN-3	Activator	/	Unkown
HY-169131	ALKBH1-IN-3 prodrug	Activator	/	Unkown
HY-RS00603	ALKBH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ALKBH1	VGNC	VGNC:69630
Bos taurus	ALKBH1	VGNC	VGNC:55101
Mus musculus	ALKBH1	MGD	MGI:2384034
Canis familiaris	ALKBH1	VGNC	VGNC:50620
Felis catus	ALKBH1	VGNC	VGNC:81038
Rattus norvegicus	ALKBH1	RGD	RGD:1308327

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