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ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA.

For research use only. We do not sell to patients.

ALKBH1-IN-1 Chemical Structure

ALKBH1-IN-1 Chemical Structure

Size Price Stock Quantity
5 mg USD 135 In-stock
10 mg USD 220 In-stock
25 mg USD 465 In-stock
50 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA[1].

In Vitro

ALKBH1-IN-1 (3 μM, 48 h) stabilizes the ALKBH1 protein in U251 cells overexpressed with ALKBH1[1].
ALKBH1-IN-1 (10 μM, 48 h) increases the amount of 6mA in DNA in U251 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

380.28

Formula

C16H11F3N4O4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C2=NC=C(OCC3=CC=CC(OC(F)(F)F)=C3)C=N2)N=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (262.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6296 mL 13.1482 mL 26.2964 mL
5 mM 0.5259 mL 2.6296 mL 5.2593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6296 mL 13.1482 mL 26.2964 mL 65.7410 mL
5 mM 0.5259 mL 2.6296 mL 5.2593 mL 13.1482 mL
10 mM 0.2630 mL 1.3148 mL 2.6296 mL 6.5741 mL
15 mM 0.1753 mL 0.8765 mL 1.7531 mL 4.3827 mL
20 mM 0.1315 mL 0.6574 mL 1.3148 mL 3.2871 mL
25 mM 0.1052 mL 0.5259 mL 1.0519 mL 2.6296 mL
30 mM 0.0877 mL 0.4383 mL 0.8765 mL 2.1914 mL
40 mM 0.0657 mL 0.3287 mL 0.6574 mL 1.6435 mL
50 mM 0.0526 mL 0.2630 mL 0.5259 mL 1.3148 mL
60 mM 0.0438 mL 0.2191 mL 0.4383 mL 1.0957 mL
80 mM 0.0329 mL 0.1644 mL 0.3287 mL 0.8218 mL
100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6574 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ALKBH1-IN-1
Cat. No.:
HY-163385
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