STK19 - serine/threonine kinase 19 Gene

Homo sapiens

Also known as G11; RP1; D6S60; D6S60E; HLA-RP1

Gene ID: 8859 | Gene type: protein coding

About STK19

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,971,175-31,981,446 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele and 183 orthologues. Ubiquitous expression in adrenal (RPKM 19.3), testis (RPKM 9.7) and 25 other tissues.

Summary

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]

STK19 Products(2)

mRNA	Protein	Name
NM_004197.2	NP_004188.2	serine/threonine-protein kinase 19 isoform 1
NM_032454.1	NP_115830.1	serine/threonine-protein kinase 19 isoform 2

STK19 Protein Structure

Stk19

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 19

MHC class III HLA-RP1

STK19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STK19	P49842	ASB3	Homo sapiens	Q9Y575	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skin Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Skin	Epidermoid Skin Carcinoma
Squamous Cell Carcinoma Of The Skin	Squamous Cell Epithelioma Of Skin
Cutaneous Squamous Cell Carcinoma	Scc - [Squamous Cell Carcinoma] Of Skin

Skin Melanoma

Cutaneous Melanoma	Malignant Ear Melanoma
Malignant Lip Melanoma	Malignant Lower Limb Melanoma
Malignant Melanoma Of Ear And/Or External Auricular Canal	Malignant Melanoma Of Skin Of Lower Limb
Malignant Melanoma Of Skin Of Trunk Except Scrotum	Malignant Melanoma Of Skin Of Upper Limb
Malignant Neck Melanoma	Malignant Scalp Melanoma
Malignant Trunk Melanoma	Malignant Upper Limb Melanoma
Melanoma, Cutaneous Malignant	Melanoma
Malignant Melanoma Of Skin	Melanoma Nos
Malignant Mole, Meaning Melanoma Of Unspecified Site	Melanoma Of Unspecified Site
Cutaneous Malignant Melanoma	Mm - [Malignant Melanoma]

Hyperpigmentation Of The Skin

Retinitis Pigmentosa 4

RP4	Retinitis Pigmentosa 4, Autosomal Dominant Or Recessive
Retinitis Pigmentosa, Rhodopsin-Related	Retinitis Pigmentosa, Type 4

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Retinitis Pigmentosa 3

RP3	Retinitis Pigmentosa 15
Rp15	Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women
Cone-Rod Degeneration, X-Linked	Retinitis Pigmentosa Type 15
X-Linked Cone-Rod Degeneration	X-Linked Retinitis Pigmentosa 3
Xlrp3	Xlrp-3
Retinitis Pigmentosa-3	Retinitis Pigmentosa, Type 3

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122866	ZT-12-037-01	Inhibitor	98.06%	Unkown
HY-RS13926	STK19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STK19	RGD	RGD:1359601
Macaca mulatta	STK19	VGNC	VGNC:83471
Mus musculus	STK19	MGD	MGI:1860085
Bos taurus	STK19	VGNC	VGNC:35389

Name
Email *

	Sorry, but the email address you supplied was invalid.