PER3 - period circadian regulator 3 Gene

Homo sapiens

Also known as GIG13; FASPS3

Gene ID: 8863 | Gene type: protein coding

About PER3

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,784,291-7,845,177 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 14.6), fat (RPKM 11.2) and 24 other tissues.

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

PER3 Products(7)

mRNA	Protein	Name
NM_001289861.2	NP_001276790.1	period circadian protein homolog 3 isoform 2
NM_001289862.2	NP_001276791.1	period circadian protein homolog 3 isoform 1
NM_001289863.3	NP_001276792.1	period circadian protein homolog 3 isoform 3
NM_001289864.3	NP_001276793.1	period circadian protein homolog 3 isoform 5
NM_001377275.1	NP_001364204.1	period circadian protein homolog 3 isoform 1
NM_001377276.1	NP_001364205.1	period circadian protein homolog 3 isoform 6
NM_016831.4	NP_058515.1	period circadian protein homolog 3 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21070773	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26903630	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	26903630	GOA
involved in regulation of circadian sleep/wake cycle, sleep	IMP IMP: Inferred from mutant phenotype	17346965	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26903630	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26903630	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

period circadian protein homolog 3

cell growth-inhibiting gene 13 protein

Related Diseases

Diseases

Alias

Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3	FASPS3
Familial Advanced Sleep Phase Syndrome 3	Sleep Phase Syndrome, Advanced, Familial, Type 3

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Bile Duct Cystadenoma

Cystadenoma Of The Bile Duct

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Gum Cancer

Malignant Neoplasm Of Gum	Malignant Tumor Of Gum
Malignant Gingival Tumor	Malignant Neoplasm Of Other Sites Of Gum
Malignant Tumour Of Gingiva

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Periodic Limb Movement Disorder

Nocturnal Myoclonus Syndrome

Nocturnal Myoclonus

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10333	PER3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PER3	RGD	RGD:621581
Macaca mulatta	PER3	VGNC	VGNC:100031
Canis familiaris	PER3	VGNC	VGNC:44422
Mus musculus	PER3	MGD	MGI:1277134

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