PER1 - period circadian regulator 1 Gene

Homo sapiens

Also known as PER; hPER; RIGUI

Gene ID: 5187 | Gene type: protein coding

About PER1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,140,472-8,152,404 (from NCBI)

This gene has 19 transcripts (splice variants), 212 orthologues, 2 paralogues and is associated with 70 phenotypes. Ubiquitous expression in bone marrow (RPKM 31.1), ovary (RPKM 28.6) and 25 other tissues.

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]

PER1 Products(1)

mRNA	Protein	Name
NM_002616.3	NP_002607.2	period circadian protein homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables E-box binding	IDA IDA: Inferred from direct assay	18411297	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18411297	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	15917222	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23503662	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15917222	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	18411297	GOA
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	14645221	GOA
involved in regulation of hair cycle	IMP IMP: Inferred from mutant phenotype	24005054	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24005054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PER1 Protein Structure

PAS_11

Period_C

0
200
400
600
800
1000
1200
1290 a.a.

Protein Preferred Names

Protein Names

period circadian protein homolog 1

Period, drosophila, homolog of

PER1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PER1	O15534	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	PER1	O15534	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	PER1	O15534	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	PER1	O15534	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	PER1	O15534	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Intra	PER1	O15534	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	PER1	O15534	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	PER1	O15534	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	PER1	O15534	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	PER1	O15534	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	PER1	O15534	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	PER1	O15534	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	PER1	O15534	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	PER1	O15534	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	PER1	O15534	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	PER1	O15534	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	PER1	O15534	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	PER1	O15534	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	PER1	O15534	PLP1	Homo sapiens	P60201-2	Y2H Pooling	32814053
Intra	PER1	O15534	PLP1	Homo sapiens	P60201-2	Validated Y2H	32814053
Intra	PER1	O15534	PLP1	Homo sapiens	P60201-2	Y2H Array	32814053
Intra	PER1	O15534	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	PER1	O15534	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	PER1	O15534	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	PER1	O15534	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	PER1	O15534	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	PER1	O15534	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	PER1	O15534	ST13	Homo sapiens	Q9P1I4	Y2H Array	32814053
Intra	PER1	O15534	ST13	Homo sapiens	Q9P1I4	Y2H Pooling	32814053
Intra	PER1	O15534	ST13	Homo sapiens	Q9P1I4	Validated Y2H	32814053
Intra	PER1	O15534	RAN	Homo sapiens	P62826	Validated Y2H	32814053
Intra	PER1	O15534	RAN	Homo sapiens	P62826	Y2H Array	32814053
Intra	PER1	O15534	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
Intra	PER1	O15534	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PER1	O15534	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PER1	O15534	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PER1	O15534	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	PER1	O15534	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	PER1	O15534	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	PER1	O15534	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	PER1	O15534	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	PER1	O15534	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	PER1	O15534	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PER1	O15534	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PER1	O15534	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PER1	O15534	HSPA2	Homo sapiens	P54652	Validated Y2H	32814053
Intra	PER1	O15534	HSPA2	Homo sapiens	P54652	Y2H Array	32814053
Intra	PER1	O15534	HSPA2	Homo sapiens	P54652	Y2H Pooling	32814053
Intra	PER1	O15534	CCT7	Homo sapiens	Q99832	Y2H Array	32814053
Intra	PER1	O15534	CCT7	Homo sapiens	Q99832	Y2H Pooling	32814053
Intra	PER1	O15534	CCT7	Homo sapiens	Q99832	Validated Y2H	32814053
Intra	PER1	O15534	NUPR1	Homo sapiens	O60356	Y2H Pooling	32814053
Intra	PER1	O15534	NUPR1	Homo sapiens	O60356	Validated Y2H	32814053
Intra	PER1	O15534	NUPR1	Homo sapiens	O60356	Y2H Array	32814053
Intra	PER1	O15534	P4HB	Homo sapiens	P07237	Y2H Pooling	32814053
Intra	PER1	O15534	P4HB	Homo sapiens	P07237	Validated Y2H	32814053
Intra	PER1	O15534	P4HB	Homo sapiens	P07237	Y2H Array	32814053
Intra	PER1	O15534	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
Intra	PER1	O15534	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
Intra	PER1	O15534	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
Intra	PER1	O15534	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
Intra	PER1	O15534	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
Intra	PER1	O15534	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
Intra	PER1	O15534	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	PER1	O15534	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	PER1	O15534	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	PER1	O15534	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PER1	O15534	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PER1	O15534	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PER1	O15534	CRY1	Homo sapiens	Q16526	Anti Tag CoIP	28514442
Intra	PER1	O15534	CRY1	Homo sapiens	Q16526	Anti Tag CoIP	33961781
Intra	PER1	O15534	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	PER1	O15534	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	PER1	O15534	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	PER1	O15534	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	PER1	O15534	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	PER1	O15534	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	PER1	O15534	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	PER1	O15534	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	PER1	O15534	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	PER1	O15534	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	PER1	O15534	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	PER1	O15534	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder	Rem Sleep Behaviour Disorder
Rapid Eye Movement Sleep Behaviour Disorder	Rem - [Rapid Eye Movement] Behaviour Disorder

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Moebius Syndrome

Mobius Syndrome	Moebius Sequence
Oromandibular-Limb Hypogenesis Spectrum	Congenital Facial Diplegia
MBS	Moebius Congenital Oculofacial Paralysis
Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves	Congenital Facial Diplegia Syndrome
Congenital Oculofacial Paralysis	Congenital Ophthalmoplegia And Facial Paresis
Moebius Spectrum	Möbius Sequence
Möbius Syndrome	Mobius Ii Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125145	AA92593		98.60%	Unkown
HY-N10987	Spiranthesol		/	Unkown
HY-RS10331	PER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PER1	VGNC	VGNC:44420
Rattus norvegicus	PER1	RGD	RGD:727863
Bos taurus	PER1	VGNC	VGNC:32748
Mus musculus	PER1	MGD	MGI:1098283
Macaca mulatta	PER1	VGNC	VGNC:75942
Felis catus	PER1	VGNC	VGNC:68787

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