CDC123 - cell division cycle 123 Gene

Homo sapiens

Also known as D123; C10orf7

Gene ID: 8872 | Gene type: protein coding

About CDC123

Cytogenetic location: 10p14-p13 Genomic coordinates (GRCh38): 10:12,196,188-12,250,589 (from NCBI)

This gene has 9 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in lymph node (RPKM 28.2), appendix (RPKM 26.4) and 25 other tissues.

Summary

Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDC123 Products(1)

mRNA	Protein	Name
NM_006023.3	NP_006014.2	cell division cycle protein 123 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	37507029	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	37507029	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in eukaryotic translation initiation factor 2 complex assembly	IDA IDA: Inferred from direct assay	37507029	GOA
involved in eukaryotic translation initiation factor 2 complex assembly	IMP IMP: Inferred from mutant phenotype	37507029	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC123 Protein Structure

D123

0
100
200
300
336 a.a.

Protein Preferred Names

Protein Names

cell division cycle protein 123 homolog

HT-1080

Related Diseases

Diseases

Alias

Wolfram Syndrome 1

WFS1	Didmoad
Wfs	Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome
Wolfram Syndrome

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02284	CDC123 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDC123	RGD	RGD:619766
Bos taurus	CDC123	VGNC	VGNC:27058
Felis catus	CDC123	VGNC	VGNC:83521
Mus musculus	CDC123	MGD	MGI:2138811
Canis familiaris	CDC123	VGNC	VGNC:38985
Macaca mulatta	CDC123	VGNC	VGNC:70768

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