SKAP2 - src kinase associated phosphoprotein 2 Gene

Homo sapiens

Also known as PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM

Gene ID: 8935 | Gene type: protein coding

About SKAP2

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,654,770-26,864,590 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 10.6), appendix (RPKM 9.8) and 24 other tissues.

Summary

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

SKAP2 Products(2)

mRNA	Protein	Name
NM_001303468.2	NP_001290397.1	src kinase-associated phosphoprotein 2 isoform 2
NM_003930.5	NP_003921.2	src kinase-associated phosphoprotein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21719704	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11390434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKAP2 Protein Structure

SH3_9

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

src kinase-associated phosphoprotein 2

Fyn-associated phosphoprotein SKAP55 homologue

Related Diseases

Diseases

Alias

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency	Vertebrobasilar Arterial Insufficiency
Vertebrobasilar Artery Syndrome

Candida Glabrata

Torulopsis Glabrata

Spinocerebellar Ataxia, Autosomal Recessive 3

SCAR3	Scabd
Autosomal Recessive Spinocerebellar Ataxia Type 3	Autosomal Recessive Spinocerebellar Ataxia-Blindness-Deafness Syndrome
Autosomal Recessive Spinocerebellar Ataxia-Blindness-Hearing Loss Syndrome	Spinocerebellar Ataxia With Blindness And Deafness
Autosomal Recessive Spinocerebellar Ataxia 3	Spinocerebellar Ataxia Autosomal Recessive 3
Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness	Autosomal Recessive Cerebellar Ataxia-Blindness-Deafness Syndrome

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome	Hfgs
Hfg Syndrome	Hfu Syndrome
HFG	Hfu
Hand Foot Uterus Syndrome	Hand Foot Genital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12968	SKAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SKAP2	RGD	RGD:620159
Mus musculus	SKAP2	MGD	MGI:1889206
Canis familiaris	SKAP2	VGNC	VGNC:46197
Felis catus	SKAP2	VGNC	VGNC:65170
Bos taurus	SKAP2	VGNC	VGNC:34646
Macaca mulatta	SKAP2	VGNC	VGNC:77488

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