P4HA2 - prolyl 4-hydroxylase subunit alpha 2 Gene

Homo sapiens

Also known as MYP25; lncRNA-PE

Gene ID: 8974 | Gene type: protein coding

About P4HA2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,190,147-132,227,853 (from NCBI)

This gene has 21 transcripts (splice variants), 215 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lung (RPKM 10.5), kidney (RPKM 10.5) and 24 other tissues.

Summary

This gene encodes a component of prolyl 4-hydroxylase, a key Enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active Enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

P4HA2 Products(9)

mRNA	Protein	Name
NM_001017974.2	NP_001017974.1	prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001142598.2	NP_001136070.1	prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001142599.2	NP_001136071.1	prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor
NM_001365677.2	NP_001352606.1	prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor
NM_001365678.2	NP_001352607.1	prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001365679.2	NP_001352608.1	prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001365680.2	NP_001352609.1	prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
NM_001365681.2	NP_001352610.1	prolyl 4-hydroxylase subunit alpha-2 isoform 3 precursor
NM_004199.3	NP_004190.1	prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables procollagen-proline 4-dioxygenase activity	IDA IDA: Inferred from direct assay	9211872	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P4HA2 Protein Structure

P4Ha_N

2OG-FeII_Oxy

0
100
200
300
400
500
535 a.a.

Protein Preferred Names

Protein Names

prolyl 4-hydroxylase subunit alpha-2

4-PH alpha 2

Related Diseases

Diseases

Alias

Myopia 25, Autosomal Dominant

MYP25

Temporal Arteritis

Polymyalgia Rheumatica	Giant Cell Arteritis
Cranial Arteritis	Horton Disease
Gca	Horton'S Disease
Rhizomelic Pseudopolyarthritis	Arteritis Cranialis
Arteritis Temporalis	Horton'S Arteritis
Horton'S Giant Cell Arteritis	Horton'S Temporal Arteritis
Horton'S Syndrome	Gca - [Giant Cell Arteritis]
Senile Arthritis	Polymyalgia Arteritica
Pmr - [Polymyalgia Rheumatica]	Forestier-Certonciny Syndrome
Rheumatic Polymyalgia	Polymyalgia

Breast Scirrhous Carcinoma

Infiltrating Carcinoma Of Breast With Fibrotic Stroma

Scirrhous Carcinoma Of Breast

Refractive Error

Refractive Errors

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Osteogenesis Imperfecta, Type Viii

Osteogenesis Imperfecta Type 8	OI8
Osteogenesis Imperfecta Type Viii	Oi Type Viii
Oi, Type Viii	Osteogenesis Imperfecta 8
Oi-Viii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121172	1,4-DPCA	Inhibitor	98.49%	Unkown
HY-RS09943	P4HA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	P4HA2	VGNC	VGNC:32536
Felis catus	P4HA2	VGNC	VGNC:68677
Macaca mulatta	P4HA2	VGNC	VGNC:75742
Canis familiaris	P4HA2	VGNC	VGNC:44223
Mus musculus	P4HA2	MGD	MGI:894286
Rattus norvegicus	P4HA2	RGD	RGD:1309673

Name
Email *

	Sorry, but the email address you supplied was invalid.