KLHL6 - kelch like family member 6 Gene

Homo sapiens

Gene ID: 89857 | Gene type: protein coding

About KLHL6

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,487,551-183,555,706 (from NCBI)

This gene has 4 transcripts (splice variants), 87 orthologues and 54 paralogues. Biased expression in lymph node (RPKM 24.5), appendix (RPKM 11.9) and 10 other tissues.

Summary

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

KLHL6 Products(1)

mRNA	Protein	Name
NM_130446.4	NP_569713.2	kelch-like protein 6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL6 Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

kelch-like protein 6

KLHL6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLHL6	Q8WZ60	FH	Homo sapiens	P07954	Y2H Array	32296183
Intra	KLHL6	Q8WZ60	FH	Homo sapiens	P07954	Y2H Prey Pooling	32296183
Intra	KLHL6	Q8WZ60	TMPO	Homo sapiens	P42167	Y2H Prey Pooling	32296183
Intra	KLHL6	Q8WZ60	TMPO	Homo sapiens	P42167	Y2H Array	32296183
Intra	KLHL6	Q8WZ60	PPP1R1B	Homo sapiens	Q9UD71	Validated Y2H	25416956
Intra	KLHL6	Q8WZ60	PPP1R1B	Homo sapiens	Q9UD71	Y2H Array	25416956
Intra	KLHL6	Q8WZ60	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	33961781
Intra	KLHL6	Q8WZ60	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07370	KLHL6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLHL6	MGD	MGI:2686922
Bos taurus	KLHL6	VGNC	VGNC:30669
Macaca mulatta	KLHL6	VGNC	VGNC:74077
Felis catus	KLHL6	VGNC	VGNC:63157
Rattus norvegicus	KLHL6	RGD	RGD:1307521
Canis familiaris	KLHL6	VGNC	VGNC:42475

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