SEC16B - SEC16 homolog B, endoplasmic reticulum export factor Gene

Homo sapiens

Also known as RGPR; LZTR2; SEC16S; PGPR-p117; RGPR-p117

Gene ID: 89866 | Gene type: protein coding

About SEC16B

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:177,928,788-177,984,284 (from NCBI)

This gene has 8 transcripts (splice variants), 170 orthologues and 1 paralogue. Broad expression in small intestine (RPKM 16.8), duodenum (RPKM 16.0) and 22 other tissues.

Summary

SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

SEC16B Products(5)

mRNA	Protein	Name
NM_001356499.2	NP_001343428.1	protein transport protein Sec16B isoform 2
NM_001390833.1	NP_001377762.1	protein transport protein Sec16B isoform 1
NM_001390834.1	NP_001377763.1	protein transport protein Sec16B isoform 4
NM_001390835.1	NP_001377764.1	protein transport protein Sec16B isoform 4
NM_033127.4	NP_149118.2	protein transport protein Sec16B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum organization	IDA IDA: Inferred from direct assay	21768384	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	21478858	GOA
involved in peroxisome fission	IMP IMP: Inferred from mutant phenotype	21768384	GOA
involved in peroxisome organization	IDA IDA: Inferred from direct assay	21768384	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21768384	GOA
involved in positive regulation of protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	21768384	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	21478858	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	21768384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC16B Protein Structure

Sec16

Sec16_C

0
200
400
600
800
1000
1060 a.a.

Protein Preferred Names

Protein Names

protein transport protein Sec16B

leucine zipper transcription regulator 2

SEC16B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SEC16B	Q96JE7	SEC13	Homo sapiens	P55735	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12610	SEC16B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEC16B	VGNC	VGNC:82505
Bos taurus	SEC16B	VGNC	VGNC:34407
Rattus norvegicus	SEC16B	RGD	RGD:621658
Canis familiaris	SEC16B	VGNC	VGNC:45966
Macaca mulatta	SEC16B	VGNC	VGNC:100136
Mus musculus	SEC16B	MGD	MGI:2148802

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