2. Gene
  3. SEC13 - SEC13 homolog, nuclear pore and COPII coat complex component Gene

SEC13 - SEC13 homolog, nuclear pore and COPII coat complex component Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SEC13R; npp-20; SEC13L1; D3S1231E

Gene ID: 6396 | Gene type: protein coding

About SEC13

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,300,931-10,321,112 (from NCBI)

This gene has 19 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 31.7), small intestine (RPKM 28.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]

SEC13 Products(5)

mRNA Protein Name
NM_001136026.3 NP_001129498.1 protein SEC13 homolog isoform 3
NM_001136232.3 NP_001129704.1 protein SEC13 homolog isoform 2
NM_001278946.2 NP_001265875.1 protein SEC13 homolog isoform 5
NM_030673.4 NP_109598.2 protein SEC13 homolog isoform 4
NM_183352.3 NP_899195.1 protein SEC13 homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18160040 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15146057 GOA
Biological Process GO Annotation Evidence Reference Source
involved in COPII-coated vesicle cargo loading IDA
IDA: Inferred from direct assay
17499046 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
35831510 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35831510 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COPII vesicle coat IDA
IDA: Inferred from direct assay
17499046 GOA
part of GATOR2 complex IDA
IDA: Inferred from direct assay
35831510 GOA
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
15146057 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
28199306 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
15146057 GOA
part of nuclear pore outer ring IDA
IDA: Inferred from direct assay
17360435 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC13 Protein Structure

WD40

WD40: WD domain, G-beta repeat (5 - 41)

WD40

WD40: WD domain, G-beta repeat (51 - 86)

WD40

WD40: WD domain, G-beta repeat (93 - 130)

WD40

WD40: WD domain, G-beta repeat (140 - 195)

WD40

WD40: WD domain, G-beta repeat (202 - 243)

WD40

WD40: WD domain, G-beta repeat (263 - 290)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

protein SEC13 homolog

GATOR complex protein SEC13

SEC13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SEC13 P55735 SEC16B Homo sapiens Q96JE7-2
Validated Y2H
25416956
Intra
SEC13 P55735 SEC16B Homo sapiens Q96JE7-2
Y2H Prey Pooling
25416956
Intra
SEC13 P55735 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
33961781
Intra
SEC13 P55735 NUP37 Homo sapiens Q8NFH4
Y2H Array
27194810
Intra
SEC13 P55735 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
28514442
Intra
SEC13 P55735 NUP37 Homo sapiens Q8NFH4
Anti Tag CoIP
28514442
Intra
SEC13 P55735 NUP37 Homo sapiens Q8NFH4
Anti Tag CoIP
33961781
Intra
SEC13 P55735 SEH1L Homo sapiens Q96EE3
Anti Tag CoIP
35271311
Intra
SEC13 P55735 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
35271311
Intra
SEC13 P55735 NUP37 Homo sapiens Q8NFH4
Anti Tag CoIP
35271311
Intra
SEC13 P55735 SEH1L Homo sapiens Q96EE3
Anti Tag CoIP
33961781
Intra
SEC13 P55735 SEH1L Homo sapiens Q96EE3
Y2H Array
27194810
Cross
SEC13 P55735 NUP145 Saccharomyces cerevisiae P49687
X-Ray Diffraction
18160040
Cross
SEC13 P55735 NUP145 Saccharomyces cerevisiae P49687
GMS
18160040
Cross
SEC13 P55735 NUP145 Saccharomyces cerevisiae P49687
Y2H Array
27194810
Intra
SEC13 P55735 SEC31A Homo sapiens O94979
Anti Tag CoIP
35271311
Intra
SEC13 P55735 SEC31A Homo sapiens O94979
Anti Tag CoIP
33961781
Intra
SEC13 P55735 TRAF5 Homo sapiens O00463
Validated Y2H
25416956
Intra
SEC13 P55735 TRAF5 Homo sapiens O00463
Y2H Array
25416956
Intra
SEC13 P55735 SEC16B Homo sapiens Q96JE7
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii

CDAN2

Cda Ii

Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test

Cda Type Ii

Congenital Dyserythropoietic Anemia Type 2

Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test

Sec23b-Cdg

Congenital Dyserythropoietic Anemia, Type Ii

Dyserythropoietic Anemia, Hempas Type

Hempas

Cda Type 2

Dyserythropoietic Anemia, Congenital, Type Ii

Cda, Type Ii

Congenital Dyserythropoietic Anaemia Type 2

Congenital Dyserythropoietic Anaemia Type Ii

Anemia, Dyserythropoietic, Congenital Type 2

Hempas Anemia

Dyserythropoietic Anemia, Congenital Type 2

Anemia, Congenital Dyserythropoietic, 2

Dyserythropoietic Anemia Hempas Type

Anemia, Dyserythropoietic Congenital, Type Ii

Anemia, Dyserythropoietic, Congenital, Type Ii
Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12605 SEC13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SEC13 VGNC VGNC:77149
Felis catus SEC13 VGNC VGNC:64960
Bos taurus SEC13 VGNC VGNC:34403
Rattus norvegicus SEC13 RGD RGD:1359555
Canis familiaris SEC13 VGNC VGNC:45962
Mus musculus SEC13 MGD MGI:99832