RHOT2 - ras homolog family member T2 Gene

Homo sapiens

Also known as RASL; ARHT2; MIRO2; MIRO-2; C16orf39

Gene ID: 89941 | Gene type: protein coding

About RHOT2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:668,083-674,174 (from NCBI)

This gene has 28 transcripts (splice variants), 195 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 20.5), duodenum (RPKM 16.0) and 25 other tissues.

Summary

This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]

RHOT2 Products(21)

mRNA	Protein	Name
NM_001352275.2	NP_001339204.1	mitochondrial Rho GTPase 2 isoform 1
NM_001352276.2	NP_001339205.1	mitochondrial Rho GTPase 2 isoform 3
NM_001352277.2	NP_001339206.1	mitochondrial Rho GTPase 2 isoform 4
NM_001352278.2	NP_001339207.1	mitochondrial Rho GTPase 2 isoform 5
NM_001352279.2	NP_001339208.1	mitochondrial Rho GTPase 2 isoform 6
NM_001352280.2	NP_001339209.1	mitochondrial Rho GTPase 2 isoform 7
NM_001352281.2	NP_001339210.1	mitochondrial Rho GTPase 2 isoform 8
NM_001352282.2	NP_001339211.1	mitochondrial Rho GTPase 2 isoform 8
NM_001352283.2	NP_001339212.1	mitochondrial Rho GTPase 2 isoform 9
NM_001352284.2	NP_001339213.1	mitochondrial Rho GTPase 2 isoform 10
NM_001352285.2	NP_001339214.1	mitochondrial Rho GTPase 2 isoform 11
NM_001352286.2	NP_001339215.1	mitochondrial Rho GTPase 2 isoform 12
NM_001352287.1	NP_001339216.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352288.2	NP_001339217.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352289.2	NP_001339218.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352290.2	NP_001339219.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352291.2	NP_001339220.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352292.2	NP_001339221.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352293.2	NP_001339222.1	mitochondrial Rho GTPase 2 isoform 13
NM_001352294.2	NP_001339223.1	mitochondrial Rho GTPase 2 isoform 13
NM_138769.3	NP_620124.1	mitochondrial Rho GTPase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16630562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular homeostasis	IMP IMP: Inferred from mutant phenotype	12482879	GOA
involved in mitochondrial outer membrane permeabilization	IMP IMP: Inferred from mutant phenotype	12482879	GOA
involved in mitochondrion transport along microtubule	IMP IMP: Inferred from mutant phenotype	16630562	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12482879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOT2 Protein Structure

Ras

EF_assoc_2

EF_assoc_1

Roc

0
100
200
300
400
500
618 a.a.

Protein Preferred Names

Protein Names

mitochondrial Rho GTPase 2

mitochondrial Rho (MIRO) GTPase 2

RHOT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHOT2	Q8IXI1	TRAK1	Homo sapiens	Q9UPV9	Confocal	16630562
Intra	RHOT2	Q8IXI1	TRAK1	Homo sapiens	Q9UPV9	Anti Tag CoIP	24995978
Intra	RHOT2	Q8IXI1	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	RHOT2	Q8IXI1	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	RHOT2	Q8IXI1	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	RHOT2	Q8IXI1	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	RHOT2	Q8IXI1	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	RHOT2	Q8IXI1	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	RHOT2	Q8IXI1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	RHOT2	Q8IXI1	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	RHOT2	Q8IXI1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11958	RHOT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RHOT2	VGNC	VGNC:45564
Bos taurus	RHOT2	VGNC	VGNC:33954
Macaca mulatta	RHOT2	VGNC	VGNC:76796
Rattus norvegicus	RHOT2	RGD	RGD:727970
Mus musculus	RHOT2	MGD	MGI:2384892
Felis catus	RHOT2	VGNC	VGNC:64618

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