2. Gene
  3. SAR1A - secretion associated Ras related GTPase 1A Gene

SAR1A - secretion associated Ras related GTPase 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAR1; Sara; SARA1; masra2

Gene ID: 56681 | Gene type: protein coding

About SAR1A

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,147,289-70,170,514 (from NCBI)

This gene has 8 transcripts (splice variants), 121 orthologues and 30 paralogues. Ubiquitous expression in fat (RPKM 47.2), placenta (RPKM 41.9) and 25 other tissues.

Summary

Predicted to enable GTPase activity. Involved in COPII-coated vesicle cargo loading. Part of COPII vesicle coat. [provided by Alliance of Genome Resources, Apr 2022]

SAR1A Products(2)

mRNA Protein Name
NM_001142648.2 NP_001136120.1 GTP-binding protein SAR1a
NM_020150.5 NP_064535.1 GTP-binding protein SAR1a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein activity IDA
IDA: Inferred from direct assay
32358066 GOA
enables amino acid sensor activity IDA
IDA: Inferred from direct assay
34290409 GOA
enables amino acid sensor activity IMP
IMP: Inferred from mutant phenotype
34290409 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19181664 GOA
Biological Process GO Annotation Evidence Reference Source
involved in COPII vesicle coating IDA
IDA: Inferred from direct assay
32358066 GOA
involved in COPII vesicle coating IMP
IMP: Inferred from mutant phenotype
23433038 GOA
involved in COPII-coated vesicle cargo loading IDA
IDA: Inferred from direct assay
17499046 GOA
involved in COPII-coated vesicle cargo loading IMP
IMP: Inferred from mutant phenotype
23433038 GOA
involved in cellular response to leucine starvation IMP
IMP: Inferred from mutant phenotype
34290409 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
23433038 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
23433038 GOA
NOT involved in lipoprotein transport IDA
IDA: Inferred from direct assay
32358066 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
34290409 GOA
involved in regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
34290409 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COPII vesicle coat IDA
IDA: Inferred from direct assay
17499046 GOA
is active in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
23433038 GOA
is active in endoplasmic reticulum exit site IMP
IMP: Inferred from mutant phenotype
23433038 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
34290409 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAR1A Protein Structure

Arf

Arf: ADP-ribosylation factor family (12 - 197)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

GTP-binding protein SAR1a

COPII-associated small GTPase

SAR1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SAR1A Q9NR31 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
SAR1A Q9NR31 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
SAR1A Q9NR31 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
SAR1A Q9NR31 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
SAR1A Q9NR31 ADGRE2 Homo sapiens Q9UHX3
Validated Y2H
32296183
Intra
SAR1A Q9NR31 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
SAR1A Q9NR31 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
Intra
SAR1A Q9NR31 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra
SAR1A Q9NR31 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra
SAR1A Q9NR31 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Intra
SAR1A Q9NR31 SAR1B Homo sapiens Q9Y6B6
Anti Tag CoIP
33961781
Intra
SAR1A Q9NR31 SAR1B Homo sapiens Q9Y6B6
Anti Tag CoIP
28514442
Intra
SAR1A Q9NR31 GOLT1B Homo sapiens Q9Y3E0
Validated Y2H
32296183
Intra
SAR1A Q9NR31 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
SAR1A Q9NR31 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Cross
SAR1A Q9NR31 Sec23a Mus musculus Q01405
Pull Down
19822759
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia Tarda

SEDT

Sed Tarda, X-Linked

Spondyloepiphyseal Dysplasia, Late

Spondyloepiphyseal Dysplasia Tarda X-Linked

Sed

X Linked Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia

Late Onset Spondyloepiphyseal Dysplasia

Sed Tarda

X-Linked Sed

X-Linked Sedt

Dysplasia, Spondyloepiphyseal, Tarda

Spondyloepiphyseal Dysplasia
Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Oculomotor Nerve Paralysis

Iii Nerve Palsy

Iiird Nerve Paralysis

Third Cranial Nerve Paralysis
Intracranial Hypotension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12442 SAR1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SAR1A VGNC VGNC:76969
Bos taurus SAR1A VGNC VGNC:34286
Rattus norvegicus SAR1A RGD RGD:1359540
Mus musculus SAR1A MGD MGI:98230