MED30 - mediator complex subunit 30 Gene

Homo sapiens

Also known as MED30S; THRAP6; TRAP25

Gene ID: 90390 | Gene type: protein coding

About MED30

Cytogenetic location: 8q24.11 Genomic coordinates (GRCh38): 8:117,520,713-117,540,262 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 5.0) and 24 other tissues.

Summary

The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]

MED30 Products(3)

mRNA	Protein	Name
NM_001282986.2	NP_001269915.1	mediator of RNA polymerase II transcription subunit 30 isoform 2
NM_001363182.2	NP_001350111.1	mediator of RNA polymerase II transcription subunit 30 isoform 3
NM_080651.4	NP_542382.1	mediator of RNA polymerase II transcription subunit 30 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21784977	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12218053	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED30 Protein Structure

Med30

0
100
178 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 30

TRAP/Mediator complex component TRAP25

MED30 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED30	Q96HR3	DOCK8	Homo sapiens	Q8NF50-2	Y2H Array	25416956
Intra	MED30	Q96HR3	NAP1L2	Homo sapiens	Q9ULW6	Validated Y2H	32296183
Intra	MED30	Q96HR3	MED28	Homo sapiens	Q9H204	TAP	24981860
Intra	MED30	Q96HR3	MED28	Homo sapiens	Q9H204	Validated Y2H	32296183
Intra	MED30	Q96HR3	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	MED30	Q96HR3	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183
Intra	MED30	Q96HR3	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects

Cornelia De Lange Syndrome 4	CDLS4
Cornelia De Lange Syndrome, Type 4

Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome	Lgs
Trichorhinophalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome Type 2
TRPS2	Monosomy 8q24.1
Chromosome 8q24.1 Deletion Syndrome	Deletion 8q24.1
Giedion-Langer Syndrome	Trichorhinophalangeal Dysplasia Type Ii
Langer Giedion Syndrome	Trps 2
Tricho-Rhino-Phalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome With Exostosis
Trps Ii	Tricho-Rhino-Phalangeal Syndrome 2
8q24.1 Microdeletion Syndrome	8q24.1 Deletion Syndrome

Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases	Acoustic Nerve Disease
Cochlear Nerve Diseases	Disturbance Of Vestibulocochlear Nerve
Auditory Nerve Disorder	Disorder Of Acoustovestibular Nerve
Disorder Of Eighth Nerve	Eighth Cranial Nerve Disorder
Disease Of Eighth Cranial Nerve	Disease Of Acoustic Nerve
Disease Of Auditory Nerve	Disorder Of 8th Cranial Nerve
Auditory Nerve Lesion	Cochlear Nerve Disorder

Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis

Herpes Zoster Oticus

Nervus Intermedius Neuralgia	Ramsay Hunt Syndrome Type 2
Geniculate Herpes Zoster	Geniculate Neuralgia
Herpes Zoster Auricularis	Herpetic Geniculate Ganglionitis
Ramsay Hunt Syndrome Type Ii	Ramsey Hunt Syndrome
Facial Nerve Palsy Due To Vzv	Facial Nerve Palsy Due To Herpes Zoster Infection
Facial Nerve Paralysis Due To Vzv	Hunt Syndrome
Hunt'S Syndrome	Ramsay Hunt Syndrome
Myoclonus And Ataxia

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08301	MED30 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MED30	VGNC	VGNC:43137
Bos taurus	MED30	VGNC	VGNC:31366
Mus musculus	MED30	MGD	MGI:1917040
Rattus norvegicus	MED30	RGD	RGD:1309369
Macaca mulatta	MED30	VGNC	VGNC:74556
Felis catus	MED30	VGNC	VGNC:63441

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