MED28 - mediator complex subunit 28 Gene

Homo sapiens

Also known as EG1; magicin; 1500003D12Rik

Gene ID: 80306 | Gene type: protein coding

About MED28

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,614,641-17,634,105 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in ovary (RPKM 18.1), placenta (RPKM 17.9) and 25 other tissues.

Summary

Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and stem cell population maintenance. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MED28 Products(1)

mRNA	Protein	Name
NM_025205.5	NP_079481.2	mediator of RNA polymerase II transcription subunit 28

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10656681	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED28 Protein Structure

Med28

0
100
178 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 28

endothelial-derived gene 1

MED28 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240	Anti Bait CoIP	15467741
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240-1	Pull Down	15467741
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240-1	Anti Tag CoIP	15467741
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H Prey Pooling	25416956
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H Array	25416956
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H	21516116
Intra	MED28	Q9H204	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	MED28	Q9H204	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	LCK	Homo sapiens	P06239	Anti Bait CoIP	16899217
Intra	MED28	Q9H204	LCK	Homo sapiens	P06239	Protein Kinase Assay	16899217
Intra	MED28	Q9H204	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Cross	MED28	Q9H204	Med30	Mus musculus	Q9CQI9	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MAGI3	Homo sapiens	Q5TCQ9	Peptide Array	16964398
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED6	Homo sapiens	O75586	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED6	Homo sapiens	O75586	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Y2H Array	32296183
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	GRB2	Homo sapiens	P62993	Far-WB	16899217
Intra	MED28	Q9H204	FYN	Homo sapiens	P06241	Anti Bait CoIP	16899217
Intra	MED28	Q9H204	FYN	Homo sapiens	P06241	Y2H	16899217
Intra	MED28	Q9H204	YES1	Homo sapiens	P07947	Anti Bait CoIP	16964398
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Pull Down	16899217
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Anti Bait CoIP	16964398
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Peptide Array	16964398
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Cross	MED28	Q9H204	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08299	MED28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED28	VGNC	VGNC:107347
Rattus norvegicus	MED28	RGD	RGD:1305875
Canis familiaris	MED28	VGNC	VGNC:43135
Macaca mulatta	MED28	VGNC	VGNC:74569
Mus musculus	MED28	MGD	MGI:1914249
Bos taurus	MED28	VGNC	VGNC:31364

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