2. Gene
  3. MCU - mitochondrial calcium uniporter Gene

MCU - mitochondrial calcium uniporter Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HsMCU; C10orf42; CCDC109A

Gene ID: 90550 | Gene type: protein coding

About MCU

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,692,143-72,887,694 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in stomach (RPKM 19.3), colon (RPKM 14.7) and 24 other tissues.

Summary

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

MCU Products(3)

mRNA Protein Name
NM_001270679.2 NP_001257608.1 calcium uniporter protein, mitochondrial isoform 2 precursor
NM_001270680.3 NP_001257609.1 calcium uniporter protein, mitochondrial isoform 3
NM_138357.3 NP_612366.1 calcium uniporter protein, mitochondrial isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
21685888 GOA
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
23755363 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21685886 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21685886 GOA
enables uniporter activity IDA
IDA: Inferred from direct assay
21685886 GOA
enables uniporter activity IMP
IMP: Inferred from mutant phenotype
23755363 GOA
Biological Process GO Annotation Evidence Reference Source
involved in calcium import into the mitochondrion IDA
IDA: Inferred from direct assay
22925203 GOA
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
23755363 GOA
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
21685886 GOA
involved in cellular response to calcium ion starvation IMP
IMP: Inferred from mutant phenotype
32494073 GOA
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
22829870 GOA
involved in mitochondrial calcium ion homeostasis IDA
IDA: Inferred from direct assay
32494073 GOA
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
21685888 GOA
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21685886 GOA
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22829870 GOA
involved in positive regulation of mitochondrial calcium ion concentration IDA
IDA: Inferred from direct assay
21685888 GOA
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
21685886 GOA
involved in positive regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
28388446 GOA
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
28388446 GOA
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
21685886 GOA
Cellular Component GO Annotation Evidence Reference Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
23755363 GOA
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
31080062 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
21685886 GOA
part of uniplex complex IDA
IDA: Inferred from direct assay
24231807 GOA
part of uniplex complex IPI
IPI: Inferred from physical interaction
32494073 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCU Protein Structure

MCU

MCU: Mitochondrial calcium uniporter (109 - 321)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

calcium uniporter protein, mitochondrial

coiled-coil domain-containing protein 109A

MCU Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MCU Q8NE86 SMDT1 Homo sapiens Q9H4I9
Anti Tag CoIP
32494073
Intra
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
26387864
Intra
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
IF
26387864
Intra
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
32494073
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Ischemia

Acute Coronary Syndrome
Myopathy With Extrapyramidal Signs

Proximal Myopathy With Extrapyramidal Signs

MPXPS

Myopathy, With Extrapyramidal Signs
Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary

Malignant Ovarian Endometrioid Tumor

Ovarian Endometrioid Neoplasm
Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28

SCA28

Ataxia, Spinocerebellar, Type 28
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138620 MCU-i4 Inhibitor 99.87% Unkown
HY-W194810 MCU-i11 98.42% Unkown
HY-RS08252 MCU Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MCU VGNC VGNC:63421
Rattus norvegicus MCU RGD RGD:1589771
Mus musculus MCU MGD MGI:3026965
Macaca mulatta MCU VGNC VGNC:74560
Canis familiaris MCU VGNC VGNC:43096
Bos taurus MCU VGNC VGNC:31325