2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. MCU-i11

MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth.

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MCU-i11 Chemical Structure

MCU-i11 Chemical Structure

CAS No. : 902903-59-7

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1 mg USD 200 In-stock
5 mg USD 460 In-stock
10 mg USD 650 In-stock
25 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

MCU-i11 Related Antibodies

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Description

MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth[1].

IC50 & Target

Mito_x0002_chondrial calcium uniporter (MCU)[1]
Molecular Weight

532.61

Formula

C28H28N4O5S
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(NC1=CC=C(OCC)C=C1)CN2C(N(CC3=CC=CC=C3)C(C4=C2SC5=C4CCN(C(C)=O)C5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (164.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8775 mL 9.3877 mL 18.7755 mL
5 mM 0.3755 mL 1.8775 mL 3.7551 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.42%

SDS (393 KB)

COA (253 KB) HNMR (263 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8775 mL 9.3877 mL 18.7755 mL 46.9387 mL
5 mM 0.3755 mL 1.8775 mL 3.7551 mL 9.3877 mL
10 mM 0.1878 mL 0.9388 mL 1.8775 mL 4.6939 mL
15 mM 0.1252 mL 0.6258 mL 1.2517 mL 3.1292 mL
20 mM 0.0939 mL 0.4694 mL 0.9388 mL 2.3469 mL
25 mM 0.0751 mL 0.3755 mL 0.7510 mL 1.8775 mL
30 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5646 mL
40 mM 0.0469 mL 0.2347 mL 0.4694 mL 1.1735 mL
50 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.9388 mL
60 mM 0.0313 mL 0.1565 mL 0.3129 mL 0.7823 mL
80 mM 0.0235 mL 0.1173 mL 0.2347 mL 0.5867 mL
100 mM 0.0188 mL 0.0939 mL 0.1878 mL 0.4694 mL
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MCU-i11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCU-i11902903-59-7Mitochondrial MetabolismMitochondrial calcium uniporter complexMCUInhibitorinhibitorinhibit

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