PRMT9 - protein arginine methyltransferase 9 Gene

Homo sapiens

Also known as PRMT10

Gene ID: 90826 | Gene type: protein coding

About PRMT9

Cytogenetic location: 4q31.23 Genomic coordinates (GRCh38): 4:147,637,785-147,684,163 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in adrenal (RPKM 9.7), thyroid (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]

PRMT9 Products(6)

mRNA	Protein	Name
NM_001304458.2	NP_001291387.1	protein arginine N-methyltransferase 9 isoform 2
NM_001350141.2	NP_001337070.1	protein arginine N-methyltransferase 9 isoform 3
NM_001350142.2	NP_001337071.1	protein arginine N-methyltransferase 9 isoform 2
NM_001350143.2	NP_001337072.1	protein arginine N-methyltransferase 9 isoform 5
NM_001350144.2	NP_001337073.1	protein arginine N-methyltransferase 9 isoform 6
NM_138364.4	NP_612373.2	protein arginine N-methyltransferase 9 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25737013	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	25979344	GOA
enables protein-arginine N-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	25737013	GOA
enables protein-arginine omega-N symmetric methyltransferase activity	IMP IMP: Inferred from mutant phenotype	25737013	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	25737013	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25737013	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT9 Protein Structure

TPR_2

PrmA

0
200
400
600
845 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 9

protein arginine N-methyltransferase 10

Related Diseases

Diseases

Alias

Mandibulofacial Dysostosis With Alopecia

MFDA

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155814	EML734	Inhibitor	99.48%	Unkown
HY-RS11186	PRMT9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRMT9	MGD	MGI:2142651
Rattus norvegicus	PRMT9	RGD	RGD:1306157
Macaca mulatta	PRMT9	VGNC	VGNC:76313
Bos taurus	PRMT9	VGNC	VGNC:33354
Canis familiaris	PRMT9	VGNC	VGNC:45002
Felis catus	PRMT9	VGNC	VGNC:64363

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