CD1C - CD1c molecule Gene

Homo sapiens

Also known as R7; CD1; CD1A; BDCA1

Gene ID: 911 | Gene type: protein coding

About CD1C

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,289,923-158,294,774 (from NCBI)

This gene has 2 transcripts (splice variants), 381 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 8.6), appendix (RPKM 6.9) and 15 other tissues.

Summary

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

CD1C Products(1)

mRNA	Protein	Name
NM_001765.3	NP_001756.2	T-cell surface glycoprotein CD1c precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables endogenous lipid antigen binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables exogenous lipid antigen binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables glycolipid binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables lipopeptide binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation involved in immune response	IDA IDA: Inferred from direct assay	21167756	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD1C Protein Structure

C1-set

0
100
200
300
333 a.a.

Protein Preferred Names

Protein Names

T-cell surface glycoprotein CD1c

CD1C antigen, c polypeptide

CD1C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD1C	P29017	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	CD1C	P29017	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	CD1C	P29017	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	CD1C	P29017	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	CD1C	P29017	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	CD1C	P29017	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Histiocytosis

Chronic Histiocytosis X	Hand Schuller Christian Disease
Hand-Schüller-Christian Disease	Histiocytic Syndrome
Histiocytosis, Langerhans-Cell

Follicular Dendritic Cell Sarcoma

Dendritic Cell Sarcoma	Dendritic Cell Sarcoma, Follicular
Follicular Dendritic Cell Tumour	Dendritic Cell Sarcoma, Interdigitating
Dendritic Cell Sarcoma, Not Otherwise Specified

Non-Langerhans-Cell Histiocytosis

Histiocytosis, Non-Langerhans-Cell

Non-Langerhans Cell Histiocytosis

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma

Histiocytic And Dendritic Cell Cancer

Histiocytic And Dendritic Cell

Adult Xanthogranuloma

Rhinoscleroma

Interdigitating Dendritic Cell Sarcoma

Interdigitating Cell Sarcoma	Dendritic Cell Sarcoma, Interdigitating
Reticulum Cell Sarcoma

Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma	Naevoxanthoendothelioma
Xanthoma Neviforme	Xanthogranuloma, Juvenile

Reticulohistiocytic Granuloma

Reticulohistiocytoma	Solitary Reticulohistiocytoma
Solitary Histiocytoma	Solitary Reticulohistiocytosis

Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction

Left Ventricular Noncompaction 3	Dilated Cardiomyopathy 1c
CMD1C	Cardiomyopathy, Hypertrophic, 24
Dilated Cardiomyopathy With Left Ventricular Noncompaction	Cardiomyopathy, Dilated, 1c, With Or Without Lvnc
Cmdc1	Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction
Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction	Cardiomyopathy Dilated With Left Ventricular Noncompaction
Cardiomyopathy, Familial Hypertrophic 24	CMH24
Left Ventricular Non-Compaction 3	LVNC3
Cardiomyopathy, Dilated 1c	Familial Hypertrophic Cardiomyopathy 24
Cardiomyopathy, Dilated, 1c

Multicentric Reticulohistiocytosis

Lipoid Dermatoarthritis

Giant Cell Histiocytomatosis

Erdheim-Chester Disease

Ecd	Erdheim Chester Disease
Lipoid Granulomatosis	Lipid Granulomatosis
Polyostotic Sclerosing Histiocytosis

Orbital Cancer

Malignant Neoplasm Of Orbit	Orbital Tumor
Orbital Neoplasms	Neoplasm Of Orbit Proper
Orbit Cancer	Primary Malignant Neoplasm Of Orbit
Intraorbital Cancer

Fibrosarcoma Of Bone

Malignant Histiocytosis	Malignant Fibroxanthoma
Malignant Fibrous Histiocytoma	Histiocytic Medullary Reticulosis
Nasal Type Extranodal Nk/T-Cell Lymphoma	Histiocytic Sarcoma

Langerhans Cell Histiocytosis

Histiocytosis X	Lch
Langerhans Cell Granulomatosis	Langerhans-Cell Histiocytosis
Letterer-Siwe Disease	Hashimoto-Pritzger Disease
Histiocytosis, Langerhans-Cell	Langerhan'S Cell Histiocytosis
Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes	Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes
Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes	Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb
Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck
Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb	Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Involving Spleen	Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes
Letterer-Siwe Disease Of Intrapelvic Lymph Nodes	Letterer-Siwe Disease Of Intrathoracic Lymph Nodes
Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb	Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb
Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Of Spleen	Familial Letterer-Siwe Disease
Langerhans-Cell Histiocytosis Nos

Granuloma Annulare

Granulome Annulare

Ga - [Granuloma Annulare]

Mycosis Fungoides

Mycosis Fungoides Lymphoma	Alibert-Bazin Syndrome
Granuloma Fungoides	Classic Mycosis Fungoides
Mycosis Fungoides, Alibert-Bazin Type

Histiocytosis-Lymphadenopathy Plus Syndrome

H Syndrome	Histiocytosis With Joint Contractures And Sensorineural Deafness
Faisalabad Histiocytosis	Shml
Hjcd	Rosai-Dorfman Disease
Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus	Phid
Sinus Histiocytosis And Massive Lymphadenopathy	Familial Rosai-Dorfman Disease
Slc29a3 Spectrum Disorder	Sinus Histiocytosis With Massive Lymphadenopathy
Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness	Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss
Rosai-Dorfman Disease, Familial	Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss
Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness	Rdd
Rosaï-Dorfman Disease	Slc29a3 Disorder
Destombes-Rosai-Dorfman Disease	Rosai-Dorfman-Destombes Disease
HLAS	Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss
Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness	H Disease
Sinus Histiocytosis

Cobblestone Retinal Degeneration

Paving Stone Retinal Degeneration

Paving Stone Degeneration Of Retina

Spongiotic Dermatitis

Polyclonal Hypergammaglobulinemia

Polyclonal Gammopathy

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Granulomatous Dermatitis

Histiocytic Sarcoma

Malignant Histiocytosis

Exophthalmos

Proptosis

Seborrheic Dermatitis

Seborrhoeic Dermatitis	Seborrhea
Seborrhoeic Eczema	Skin Seborrheic
Dermatitis, Seborrheic

Central Diabetes Insipidus

Neurogenic Diabetes Insipidus	Diabetes Insipidus Cranial Type
Diabetes Insipidus Neurogenic	Diabetes Insipidus Neurohypophyseal
Neurohypophyseal Diabetes Insipidus	Pituitary Diabetes Insipidus
Cdi	Doid:0081055
Diabetes Insipidus	Di - [Diabetes Insipidus]
Adh - [Antidiuretic Hormone Secretion] Deficiency	Diabetes Mellitus Insipidus
Familial Diabetes Insipidus	Antidiuretic Hormone Hyposecretion
Vasopressin Deficiency Syndrome	Primary Central Diabetes Insipidus
Vasopressin Deficiency	Vasopressin Hyposecretion
Diabetes Insipidus Secondary To Vasopressin Deficiency

Orbital Disease

Orbit

Orbital Diseases

Malignant Histiocytic Disease

Histiocytic Disorders, Malignant

Dendritic Cell Thymoma

Epithelioid Thymoma

Type B Thymoma

Large Cell Acanthoma

Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus

Lichen Disease

Otorrhea

Discharging Ear

Connective Tissue Benign Neoplasm

Soft Tissue Neoplasms	Mesenchymal Tissue Neoplasm
Neoplasm Of Soft Tissue	Neoplasm Of Soft Tissues
Soft Tissue Benign Neoplasm	Tumor Of The Soft Tissue
Soft Tissue Neoplasm

Cervical Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of The Cervix Uteri

Beach Ear

Acute Swimmer'S Ear	Acute Bacterial Inflammation Of External Ear
Acute Otitis Externa, Diffuse	Acute Swimmers' Ear
Tank Ear

Keratosis, Seborrheic

Seborrheic Keratosis	Keratosis, Seborrheic, Somatic
Basal Cell Papilloma	Keratosis Seborrheica
KERSEB

Balloon Cell Malignant Melanoma

Diencephalic Astrocytoma

Astrocytoma Of Diencephalon

T-Cell Prolymphocytic Leukemia

T Cell Prolymphocytic Leukemia	Prolymphocytic Leukemia, T-Cell Type
T-Pll	T-Cell Chronic Lymphocytic Leukemia
Lymphocytic Leukemia T-Cell Chronic	Doid:0081042
Leukemia, T-Cell, Chronic	Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Vulvar Proximal-Type Epithelioid Sarcoma

Central Epithelioid Sarcoma

Proximal-Type Epithelioid Sarcoma

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Thymus Gland Disease

Disease Of Thymus Gland

Thymus Cancer

Thymic Neoplasm	Thymic Tumor
Thymus Neoplasm	Thymus Neoplasms
Malignant Neoplasm Of Thymus	Neoplasm Of Thymus
Thymic Neoplasms	Thymoma, Familial
Thymic Carcinoma	Thymoma, Type C
Cancer Of Thymus	Malignant Tumour Of Thymus
Primary Malignant Neoplasm Of Thymus	Thymic Glandular Cancer
Thymus Gland Cancer

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W088065S1	Sodium formate-13C,d1		≥98.0%	Unkown
HY-125818S2	Cytidine-5'-triphosphate-13C,d1 dilithium		/	Unkown
HY-150628S	2-Oxobutanoic acid-13C,d1 sodium hydrate		/	Unkown
HY-B0389S20	D-Glucose-13C,d-1		/	Unkown
HY-RS02201	CD1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W042357S5	Ac-rC Phosphoramidite-13C,d1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD1C	NCBI	NCBI:717148