SLC16A3 - solute carrier family 16 member 3 Gene

Homo sapiens

Also known as MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4

Gene ID: 9123 | Gene type: protein coding

About SLC16A3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,217,934-82,240,086 (from NCBI)

This gene has 19 transcripts (splice variants), 298 orthologues and 13 paralogues. Broad expression in placenta (RPKM 10.2), appendix (RPKM 8.8) and 22 other tissues.

Summary

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked Monocarboxylate Transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

SLC16A3 Products(6)

mRNA	Protein	Name
NM_001042422.3	NP_001035887.1	monocarboxylate transporter 4
NM_001042423.3	NP_001035888.1	monocarboxylate transporter 4
NM_001206950.2	NP_001193879.1	monocarboxylate transporter 4
NM_001206951.2	NP_001193880.1	monocarboxylate transporter 4
NM_001206952.2	NP_001193881.1	monocarboxylate transporter 4
NM_004207.4	NP_004198.1	monocarboxylate transporter 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lactate:proton symporter activity	IDA IDA: Inferred from direct assay	11101640	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10921872	GOA
enables pyruvate transmembrane transporter activity	IDA IDA: Inferred from direct assay	31719150	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lactate transmembrane transport	IDA IDA: Inferred from direct assay	11101640	GOA
involved in pyruvate transmembrane transport	IDA IDA: Inferred from direct assay	31719150	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	31791063	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	21199217	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	26854723	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10921872	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A3 Protein Structure

MFS_1

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 4

monocarboxylate transporter 3

SLC16A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC16A3	O15427	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	SLC16A3	O15427	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	SLC16A3	O15427	NR2C2AP	Homo sapiens	Q86WQ0	Validated Y2H	25416956
Intra	SLC16A3	O15427	NR2C2AP	Homo sapiens	Q86WQ0	Y2H Array	25416956
Intra	SLC16A3	O15427	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	SLC16A3	O15427	HPCA	Homo sapiens	P84074	Validated Y2H	32296183
Intra	SLC16A3	O15427	HPCA	Homo sapiens	P84074	Y2H Array	32296183
Intra	SLC16A3	O15427	HPCA	Homo sapiens	P84074	Y2H Prey Pooling	32296183
Intra	SLC16A3	O15427	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	SLC16A3	O15427	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SLC16A3	O15427	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC16A3	O15427	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	SLC16A3	O15427	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	SLC16A3	O15427	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	SLC16A3	O15427	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	SLC16A3	O15427	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	SLC16A3	O15427	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	SLC16A3	O15427	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	SLC16A3	O15427	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132301	MSC-4381	Inhibitor	98.89%	Unkown
HY-RS13025	SLC16A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC16A3	MGD	MGI:1933438
Canis familiaris	SLC16A3	VGNC	VGNC:46242
Bos taurus	SLC16A3	VGNC	VGNC:34689
Macaca mulatta	SLC16A3	VGNC	VGNC:77397
Rattus norvegicus	SLC16A3	RGD	RGD:620603
Felis catus	SLC16A3	VGNC	VGNC:65210
Others	SLC16A3	NCBI

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