NR2C2AP - nuclear receptor 2C2 associated protein Gene

Homo sapiens

Also known as TRA16

Gene ID: 126382 | Gene type: protein coding

About NR2C2AP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,201,409-19,203,414 (from NCBI)

This gene has 7 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in ovary (RPKM 9.3), skin (RPKM 8.7) and 25 other tissues.

Summary

Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NR2C2AP Products(2)

mRNA	Protein	Name
NM_001300945.2	NP_001287874.1	nuclear receptor 2C2-associated protein isoform 1
NM_176880.6	NP_795361.1	nuclear receptor 2C2-associated protein isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12486131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR2C2AP Protein Structure

F5_F8_type_C

0
100
139 a.a.

Protein Preferred Names

Protein Names

nuclear receptor 2C2-associated protein

TR4 orphan receptor associated protein TRA16

NR2C2AP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NR2C2AP	Q86WQ0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	NR2C2AP	Q86WQ0	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	NR2C2AP	Q86WQ0	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	NR2C2AP	Q86WQ0	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	NR2C2AP	Q86WQ0	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	NR2C2AP	Q86WQ0	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	SLC16A3	Homo sapiens	O15427	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bare Lymphocyte Syndrome, Type Ii

Mhc Class Ii Deficiency	Bare Lymphocyte Syndrome
Major Histocompatibility Complex Class Ii Deficiency	Bare Lymphocyte Syndrome 2
Bare Lymphocyte Syndrome Type 2	Severe Combined Immunodeficiency, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group C	Bare Lymphocyte Syndrome, Type Ii, Complementation Group D
Bare Lymphocyte Syndrome Type Ii	Scid, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group A	Bare Lymphocyte Syndrome, Type Ii, Complementation Group B
Scid Due To Absent Class Ii Hla Antigens	Hla Class 1 Deficiency
Scid, Hla Class 2-Negative	Bls Type Ii
Bare Lymphocyte Syndrome Type 2, Complementation Group A	Bare Lymphocyte Syndrome Type 2, Complementation Group E
Severe Combined Immunodeficiency	Bls, Type Ii
Bls	Bare Lymphocyte Syndrome, Type Ii, Complementation Group E
Blsii	Bls Type 1
Bls 2	Scid Due To Absence Of Class Ii Hla Antigens
Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens	Immunodeficiency By Defective Expression Of Mhc Class Ii
BLS2	Bare Lymphocyte Syndrome Type Ii Complementation Group A
Bare Lymphocyte Syndrome Type Ii Complementation Group B	Bare Lymphocyte Syndrome Type Ii Complementation Group C
Bare Lymphocyte Syndrome Type Ii Complementation Group D	Bare Lymphocyte Syndrome Type Ii Complementation Group E
Bls Ii	Hereditary Mhc Class Ii Deficiency
Hla Class Ii Deficient Combined Immunodeficiency	Mhc-Ii Deficiency
Scid Hla Class Ii-Negative	Severe Combined Immunodeficiency Hla Class Ii-Negative
Bl-2	Immunodeficiency By Defective Expression Of Hla Class 2
Hla Class 2-Negative Severe Combined Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09538	NR2C2AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR2C2AP	VGNC	VGNC:32237
Macaca mulatta	NR2C2AP	VGNC	VGNC:75495
Felis catus	NR2C2AP	VGNC	VGNC:63877
Rattus norvegicus	NR2C2AP	RGD	RGD:1561190
Mus musculus	NR2C2AP	MGD	MGI:1922942
Canis familiaris	NR2C2AP	VGNC	VGNC:43948

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