SYNGR1 - synaptogyrin 1 Gene

Homo sapiens

Gene ID: 9145 | Gene type: protein coding

About SYNGR1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,349,991-39,385,575 (from NCBI)

This gene has 7 transcripts (splice variants), 242 orthologues and 3 paralogues. Biased expression in brain (RPKM 53.1), ovary (RPKM 17.1) and 11 other tissues.

Summary

This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]

SYNGR1 Products(3)

mRNA	Protein	Name
NM_004711.5	NP_004702.2	synaptogyrin-1 isoform 1a
NM_145731.4	NP_663783.1	synaptogyrin-1 isoform 1b
NM_145738.3	NP_663791.1	synaptogyrin-1 isoform 1c

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNGR1 Protein Structure

MARVEL

0
100
200
233 a.a.

Protein Preferred Names

Protein Names

synaptogyrin-1

SYNGR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SYNGR1	O43759	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly, Seizures, And Developmental Delay

MCSZ	Developmental And Epileptic Encephalopathy 10
Epileptic Encephalopathy, Early Infantile, 10	Eiee10
Dee10	Early Infantile Epileptic Encephalopathy 10

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14090	SYNGR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYNGR1	MGD	MGI:1328323
Bos taurus	SYNGR1	VGNC	VGNC:35524
Rattus norvegicus	SYNGR1	RGD	RGD:3801
Macaca mulatta	SYNGR1	VGNC	VGNC:78068

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