NOLC1 - nucleolar and coiled-body phosphoprotein 1 Gene

Homo sapiens

Also known as P130; Srp40; NOPP130; NOPP140; NS5ATP13

Gene ID: 9221 | Gene type: protein coding

About NOLC1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,152,389-102,163,870 (from NCBI)

This gene has 9 transcripts (splice variants) and 171 orthologues. Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues.

Summary

Enables protein heterodimerization activity and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]

NOLC1 Products(3)

mRNA	Protein	Name
NM_001284388.2	NP_001271317.1	nucleolar and coiled-body phosphoprotein 1 isoform 1
NM_001284389.2	NP_001271318.1	nucleolar and coiled-body phosphoprotein 1 isoform 3
NM_004741.5	NP_004732.2	nucleolar and coiled-body phosphoprotein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular function inhibitor activity	EXP EXP: Inferred from Experiment	22906532	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17620599	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	26399832	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	26399832	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neural crest cell development	IMP IMP: Inferred from mutant phenotype	26399832	GOA
involved in neural crest formation	IMP IMP: Inferred from mutant phenotype	26399832	GOA
involved in regulation of translation	IMP IMP: Inferred from mutant phenotype	26399832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOLC1 Protein Structure

SRP40_C

0
200
400
600
699 a.a.

Protein Preferred Names

Protein Names

nucleolar and coiled-body phosphoprotein 1

140 kDa nucleolar phosphoprotein

Related Diseases

Diseases

Alias

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09420	NOLC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NOLC1	VGNC	VGNC:43885
Macaca mulatta	NOLC1	VGNC	VGNC:75178
Bos taurus	NOLC1	VGNC	VGNC:32161
Mus musculus	NOLC1	MGD	MGI:1918019
Rattus norvegicus	NOLC1	RGD	RGD:621578
Felis catus	NOLC1	VGNC	VGNC:63854

Name
Email *

	Sorry, but the email address you supplied was invalid.