ARRB2 - arrestin beta 2 Gene

Homo sapiens

Also known as ARB2; ARR2; BARR2

Gene ID: 409 | Gene type: protein coding

About ARRB2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,710,632-4,721,497 (from NCBI)

This gene has 20 transcripts (splice variants), 247 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 69.2), appendix (RPKM 43.9) and 21 other tissues.

Summary

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like Arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for Arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

ARRB2 Products(7)

mRNA	Protein	Name
NM_001257328.2	NP_001244257.1	beta-arrestin-2 isoform 3
NM_001257329.2	NP_001244258.1	beta-arrestin-2 isoform 4
NM_001257330.2	NP_001244259.1	beta-arrestin-2 isoform 5
NM_001257331.2	NP_001244260.1	beta-arrestin-2 isoform 6
NM_001330064.2	NP_001316993.1	beta-arrestin-2 isoform 7
NM_004313.4	NP_004304.1	beta-arrestin-2 isoform 1
NM_199004.2	NP_945355.1	beta-arrestin-2 isoform 2

ARRB2 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
409 a.a.

Protein Preferred Names

Protein Names

beta-arrestin-2

arrestin 3

Related Diseases

Diseases

Alias

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Cecum Lymphoma

Cecal Lymphoma

Placenta Praevia

Placenta Previa	Haemorrhage From Placenta Previa
Placenta Previa Haemorrhage	Lateral Placenta
Low Implantation Of Placenta Nos Or With Haemorrhage	Total Placenta Previa
Total Placenta Praevia Nos Or With Haemorrhage	Placental Previa Haemorrhage
Pp - [Placenta Previa]	Placenta Previa Marginalis
Placenta Previa Partialis	Partial Placenta Previa
Placenta Previa Centralis	Low Implantation Of Placenta
Low Implantation Or Insertion Of Placenta	Low Insertion Of Placenta
Low Lying Placenta	Marginal Placenta
Marginal Placenta Praevia Nos Or With Haemorrhage	Marginal Placenta Previa
Marginal Placental Haemorrhage	Partial Placenta Praevia Nos Or With Haemorrhage

Retinal Degeneration

Degeneration Of Retina

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Opioid Abuse

Opioid-Related Disorders

Pain Agnosia

Analgesia

Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Morphine Dependence

Marfan Syndrome

MFS	Mfs1
Marfan'S Syndrome	Marfan Syndrome Type 1
Marfan Syndrome, Type I	Mass Phenotype
Contractural Arachnodactyly	Mass Syndrome
Octd	Overlap Connective Tissue Disease
Marfanoid Hypermobility Syndrome	Marfan Disease

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Constipation

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01029	ARRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARRB2	VGNC	VGNC:70022
Canis familiaris	ARRB2	VGNC	VGNC:38137
Bos taurus	ARRB2	VGNC	VGNC:26170
Felis catus	ARRB2	VGNC	VGNC:97355
Mus musculus	ARRB2	MGD	MGI:99474
Rattus norvegicus	ARRB2	RGD	RGD:2157

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